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Polyvinyl chloride microplastics induce changes in gene expression and organ histology along the HPG axis in Cyprinus carpio var. larvae
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Researchers exposed common carp larvae to different concentrations of PVC microplastics in their diet for 60 days and examined effects on their reproductive system. The study found that microplastic exposure significantly reduced gonad development, altered sex hormone levels, and changed the expression of genes related to reproduction and cell death along the hypothalamic-pituitary-gonadal axis. These findings suggest that PVC microplastics may negatively impact fish reproductive health by disrupting hormonal signaling and gonadal development.
The negative consequences of microplastics pollution on the health of aquatic species have garnered extensive attention. However, the mechanisms through which microplastics may cause harm in the reproductive processes of fish remain unknown. For this study, Cyprinus carpio var. was subjected to four treatments with various concentrations of PVC microplastics for 60 days, through food rationed diets (no plastic control, 10%, 20% and 30%). The gonadosomatic indices, gonad and brain histologies, sex hormone levels, and transcriptional and translational genes in the hypothalamic-pituitary-gonadal (HPG) axes of both sexes were observed. According to the results, the gonadosomatic indices were significantly decreased, gonadal development was delayed, and the level of estradiol (E2) in the females was significantly elevated. In addition, the expression levels of genes associated with the HPG axis in the brains and gonads (gnrh, gtha1, fshβ, cyp19b, erα, vtg1, dmrt1, sox9b, and cyp19a) and the transcription levels of apoptosis-related genes in the brains and gonads (caspase3, bax, and bcl-2) exhibited significant changes. Further investigation revealed that the translation levels of genes linked to sex differentiation and sex steroid hormone (cyp19b and dmrt1) were significantly altered. These findings indicated that PVC likely microplastics may have a negative impact on the reproductive system of Cyprinus carpio var. by inhibiting gonadal development, affecting the gonad and brain structures, and altering the levels of steroid hormones and the expression of HPG axis-related genes. This work provides new insights into the toxicity of microplastics in aquatic organisms by revealing that PVC microplastics are a potential threat against the reproduction of fish populations.
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Researchers conducted a 60-day feeding experiment exposing carp larvae to PVC microplastics at varying concentrations and found significant immune system disruption and organ damage. The microplastics caused liver vacuolation, intestinal villi damage, spleen inflammation, and kidney degeneration, along with elevated inflammatory markers and reactive oxygen species. The findings indicate that chronic dietary exposure to PVC microplastics can cause serious and potentially irreversible harm to freshwater fish immune function.
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Juvenile common carp exposed to polyvinyl chloride microplastics showed dose-dependent toxic effects including tissue damage, oxidative stress, and altered biochemical markers over a subacute exposure period. The results indicate that PVC microplastics are harmful to freshwater fish at ecologically relevant concentrations.
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Researchers exposed carp larvae to polyvinyl chloride microplastics in their diet for 30 and 60 days at various concentrations. The microplastics significantly inhibited growth and weight gain while causing oxidative stress, altered antioxidant enzyme activities, and changes in gene expression in the liver. Histological examination revealed tissue damage including vacuolation in the liver under higher exposure concentrations.
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