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Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
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This review examines the molecular mechanisms by which bisphenol A (BPA), a common endocrine-disrupting chemical found in plastics, may contribute to various health conditions. Researchers analyzed BPA's effects on mesenchymal stem cells and fat cell development, as well as its uses in dental, orthopedic, and industrial applications. The study suggests that BPA exposure can alter multiple molecular pathways involved in immune, metabolic, and cellular processes.
Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.
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Bisphenol A-an Overview on its Effect on Health and Environment
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This review synthesized evidence on bisphenol A (BPA) — a chemical used in polycarbonate plastics and epoxy resins — covering its sources of human exposure, endocrine-disrupting mechanisms, and associations with metabolic, reproductive, and developmental health outcomes.
Stem cells as sensitive targets of bisphenol-A: a comprehensive review of the effects across multiple populations
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This review pulls together recent research on BPA, a chemical found in plastics, food packaging, and medical devices, showing it can damage stem cells, the body's building blocks for repairing and renewing tissues. Scientists found BPA disrupts how these cells grow, use energy, and communicate, and may even cause changes that affect future generations, especially concerning since BPA often occurs alongside microplastics in our environment. While the findings raise real health concerns, researchers note that studies vary widely in design, so more standardized research is needed before we can fully understand the risk to humans.
Bisphenol A and its replacement chemicals as endocrine disruptors and obesogens
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This review summarizes how bisphenol A (BPA) and its common replacements—BPS, BPF, BPAF, and TMBPF—act as endocrine disruptors that dysregulate hormone receptors and signaling pathways, promoting metabolic disorders and obesity through mechanisms that persist even in supposedly safer substitute chemicals.
Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
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This review examines the endocrine-disrupting effects of bisphenol A (BPA), a common plastic chemical, on the cardiovascular system. Evidence indicates that BPA can impair heart function through disruption of ion channels, calcium handling, and oxidative stress, and that BPA exposure is associated with increased risk of cardiovascular conditions including atherosclerosis and hypertension.
Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α
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Researchers used RNA sequencing and molecular binding assays to show that bisphenol A and three structural analogs (BPB, BPZ, 4MeBPA) released from plastics activate estrogen receptor alpha in human breast cancer cells, upregulating genes associated with cancer cell growth, invasion, and proliferation — providing evidence that BPA substitutes share similar endocrine-disrupting potential.
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