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Titanium-doped PET nanoplastics of environmental origin as a true-to-life model of nanoplastic
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Researchers created realistic nanoplastic test material by sanding down PET bottles that contain titanium dioxide, producing particles that closely resemble the secondary nanoplastics actually found in the environment. These titanium-doped PET nanoplastics were extensively characterized and then tested on human intestinal cells, where they caused cellular stress responses. The study provides a more environmentally relevant model for studying nanoplastic health effects compared to the pristine lab-made particles typically used in research.
The increased presence of secondary micro/nanoplastics (MNPLs) in the environment requires urgent studies on their potentially hazardous effects on exposed organisms, including humans. In this context, it is essential to obtain representative MNPL samples for such purposes. In our study, we have obtained true-to-life NPLs resulting from the degradation, via sanding, of opaque PET bottles. Since these bottles contain titanium (TiO2NPs), the resulting MNPLs also contain embedded metal. The obtained PET(Ti)NPLs were extensively characterized from a physicochemical point of view, confirming their nanosized range and their hybrid composition. This is the first time these types of NPLs are obtained and characterized. The preliminary hazard studies show their easy internalization in different cell lines, without apparent general toxicity. The demonstration by confocal microscopy that the obtained NPLs contain Ti samples offers this material multiple advantages. Thus, they can be used in in vivo approaches to determine the fate of NPLs after exposure, escaping from the existing difficulties to follow up MNPLs in biological samples.
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This study assessed the genotoxic and carcinogenic potential of secondary PET nanoplastics containing titanium dioxide, derived from grinding opaque plastic milk bottles, using validated cell-based assays. Secondary PET-TiO2 nanoplastics showed genotoxic activity, indicating that real-world nanoplastics from consumer plastic waste carry measurable cancer-related risk.
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This study assessed the genotoxic and carcinogenic potential of secondary PET nanoplastics containing titanium dioxide, produced by grinding opaque plastic milk bottles, using the micronucleus assay in mammalian cells. Results revealed that these real-world secondary nanoplastics carry genotoxic risk, highlighting hazards from breakdown of everyday plastic packaging.
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