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Studies of Endocrine Disruptors: Nonylphenol and Isomers in Biological Models

Environmental Toxicology and Chemistry 2023 24 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Ana Cristina De la Parra-Guerra, Rosa Acevedo‐Barrios

Summary

This review evaluates the toxic effects of nonylphenol and nonylphenol ethoxylates, widely used industrial chemicals that degrade to endocrine-disrupting compounds, across multiple biological models including aquatic organisms, summarizing their role as environmental contaminants and neurotoxic agents.

Certain emerging pollutants are among the most widely used chemicals globally, causing widespread concern in relation to their use in products devoted to cleaniness and asepsis. Nonylphenol ethoxylate (NPEOn) is one such contaminant, along with its degradation product, nonylphenol, an active ingredient presents in nonionic surfactants used as herbicides, cosmetics, paints, plastics, disinfectants, and detergents. These chemicals and their metabolites are commonly found in environmental matrices. Nonylphenol and NPEOn, used, are particularly concerning, given their role as endocrine disruptors chemical and possible neurotoxic effects recorded in several biological models, primarily aquatic organisms. Limiting and detecting these compounds remain of paramount importance. The objective of the present review was to evaluate the toxic effects of nonylphenol and NPEOn in different biological models. Environ Toxicol Chem 2023;42:1439-1450. © 2023 SETAC.

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