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Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

Particle and Fibre Toxicology 2023 64 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Phoebe A. Stapleton, Philip Demokritou, Chelsea M. Cary, Samantha Adams, Talia Seymore, Michael Goedken, Marianne Polunas, Dilpreet Singh, K. Vayas, Vasanthi R. Sunil, Debra L. Laskin

Summary

A single inhalation exposure to polyamide (nylon) micro and nanoplastic particles impaired blood vessel function in female rats without causing obvious lung inflammation. This suggests that inhaled plastic particles may harm the cardiovascular system through pathways that do not involve the lungs directly. The finding is concerning because it means even brief exposure to airborne microplastics could affect heart and blood vessel health in ways that might go unnoticed.

Polymers

Body Systems

Cardiovascular Endocrine Immune Respiratory

Models

Rat

These data demonstrate aerosolization of MNPs in our inhalation exposure platform. Inhaled MNP aerosols were found to alter inflammatory, cardiovascular, and endocrine activity. These novel findings will contribute to a better understanding of inhaled plastic particle toxicity.

Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

Summary

Discussion