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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Reproductive & Development Sign in to save

Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway

Biology Direct 2023 12 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 40 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Yixian Wen, Wei Yang, Yixian Wen, Ruilin Bao, Ruilin Bao, Yanqing Geng, Le Hu, Yanqing Geng, Xuemei Chen, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Yingxiong Wang, Yingxiong Wang Le Hu, Qin Mao, Xuemei Chen, Xuemei Chen, Yue Zhang, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Xueqing Liu, Yixian Wen, Yingxiong Wang

Summary

Researchers found that Ti3C2 MXene nanosheets, an emerging engineered nanomaterial, disrupt sperm cell development in male mice by activating a DNA-damage signaling pathway (ATM/p53). The findings raise concerns about the reproductive safety of nanomaterials that may enter the body through environmental exposure, similar to nanoplastics.

Ti<sub>3</sub>C<sub>2</sub> nanosheet-induced disruption of proliferation and apoptosis of spermatogonia perturbed normal spermatogenic function that was mediated by ATM/p53 signaling pathway. Our findings shed more light on the mechanisms of male reproductive toxicity induced by Ti<sub>3</sub>C<sub>2</sub> nanosheets.

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