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Thoroughly Hydrophilized Electrospun Poly(<i>L</i>‐Lactide)/ Poly(<i>ε</i>‐Caprolactone) Sponges for Tissue Engineering Application
Macromolecular Bioscience2023
7 citations
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Score: 50
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Chengzhang Xu,
Seema Agarwal,
Seema Agarwal,
Chengzhang Xu,
Chengzhang Xu,
Chengzhang Xu,
Andreas Greiner
Jun Young Cheong,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Valérie Jérôme,
Seema Agarwal,
Andreas Greiner
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Xiumei Mo,
Valérie Jérôme,
Valérie Jérôme,
Andreas Greiner
Andreas Greiner
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Valérie Jérôme,
Valérie Jérôme,
Valérie Jérôme,
Andreas Greiner
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Valérie Jérôme,
Valérie Jérôme,
Valérie Jérôme,
Valérie Jérôme,
Andreas Greiner
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Andreas Greiner
Andreas Greiner
Seema Agarwal,
Andreas Greiner
Andreas Greiner
Andreas Greiner
Andreas Greiner
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Valérie Jérôme,
Valérie Jérôme,
Valérie Jérôme,
Chengzhang Xu,
Chengzhang Xu,
Ruth Freitag,
Andreas Greiner
Andreas Greiner
Andreas Greiner
Seema Agarwal,
Seema Agarwal,
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Seema Agarwal,
Ruth Freitag,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Ruth Freitag,
Seema Agarwal,
Valérie Jérôme,
Andreas Greiner
Andreas Greiner
Andreas Greiner
Seema Agarwal,
Andreas Greiner
Seema Agarwal,
Jun Young Cheong,
Seema Agarwal,
Seema Agarwal,
Seema Agarwal,
Reza Gharibi,
Ruth Freitag,
Andreas Greiner
Ruth Freitag,
Ruth Freitag,
Ruth Freitag,
Andreas Greiner
Ruth Freitag,
Andreas Greiner
Ruth Freitag,
Ruth Freitag,
Seema Agarwal,
Ruth Freitag,
Seema Agarwal,
Andreas Greiner
Ruth Freitag,
Seema Agarwal,
Ruth Freitag,
Andreas Greiner
Andreas Greiner
Andreas Greiner
Andreas Greiner
Andreas Greiner
Andreas Greiner
Summary
Researchers developed thoroughly hydrophilized biodegradable electrospun sponges from poly(L-lactide)/poly(epsilon-caprolactone) blends using surfactant treatment, demonstrating good cell compatibility and improved cell proliferation for tissue engineering applications.
Biodegradable electrospun sponges are of interest for various applications including tissue engineering, drug release, dental therapy, plant protection, and plant fertilization. Biodegradable electrospun poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) blend fiber-based sponge with hierarchical pore structure is inherently hydrophobic, which is disadvantageous for application in tissue engineering, fertilization, and drug delivery. Contact angles and model studies for staining with a hydrophilic dye for untreated, plasma-treated, and surfactant-treated PLLA/PCL sponges are reported. Thorough hydrophilization of PLLA/PCL sponges is found only with surfactant-treated sponges. The MTT assay on the leachates from the sponges does not indicate any cell incompatibility. Furthermore, the cell proliferation and penetration of the hydrophilized sponges are verified by in vitro cell culture studies using MG63 and human fibroblast cells.