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7. The Evolutionary Imprint of Physical Evolution in Modern Cells

Zenodo (CERN European Organization for Nuclear Research) 2025
Mikuláš, Peter

Summary

This essay proposes that modern cells preserve a structural imprint from prebiotic physical evolution, with membranes functioning as physical filters shaped by tension, curvature, and permeability that predate and constrain biochemical regulation. The author argues that nanoplastics and other physical disruptors interfere with this ancient membrane architecture, shifting control from physical to biochemical cellular systems.

This essay explains what aspects of prebiotic physical evolution have been preserved in modern cells. According to our hypothesis, modern cellular systems retain a deep structural and functional imprint from the era when physics dominated and chemistry acted only as a supplier of material. Membranes and lipid rafts remain fundamentally physical structures shaped by tension, curvature, permeability, and microdomain formation. When these physical filters fail—such as in the case of nanoplastics, toxins, osmotic stress, or mechanical deformation—control shifts to biochemical signaling and regulation. This transition mirrors the ancient prebiotic dynamic, where physical stability governed raft behavior until chemistry introduced new reactions and feedback mechanisms. Modern cells thus preserve a direct evolutionary echo of the primordial competition between physics and chemistry.

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