CiteSpace bibliometric-based analysis of fluorescent probes in brain diseases

Abstract Background Fluorescent probes are used to detect and label the corresponding substances and play an important role in the detection of brain diseases. However, the general research trends in this field are poorly understood. This article explores trends in the application of fluorescent probes in brain diseases from a bibliometric perspective. Aim This holistic bibliometric analysis aim to provide a general overview of the recent advancement and the hotspots in the field of fluorescent probe from 2002 to 2022. Materials and Methods Publication between January 1 2002 and December 31 2022, relate to fluorescent probes and brain diseases research are acquired from the Web of Science Core Collection (WOSCC) database. Analysis of the volume of keyword occurrences use VOSviewer software, Scimago Graphica software is applied to country analysis, and keyword clustering, author collaboration, and institutional collaboration use CiteSpace software. Results A total of 1927 publications are extracted from the WOSCC databases. Publications are mainly from China. The keywords are divided into seven clusters, including multiple sclerosis, tumor, oxidative stress, alzheimers disease, reactive oxygen species, plasma, infection; of which, gene, single nucleotide polymorphism, schizophrenia, haplotype, apolipoprotein e, bipolar disorder are the original research hotspot in the field. Peptide, biosensor, aggregation induced emission are the main areas researched in recent years. Conclusion Current research on fluorescent probes and brain disorders have attracted increasing attention in the past two decades. This study provides a comprehensive view to understand the research trends, hot topics of research and research progress in this field.