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Toxic effects of tire wear particles and the leachate on the Chinese mitten crab (Eriocheir sinensis)

Environmental Pollution 2023 36 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Xianliang Yi, Yang Liu, Xianliang Yi, Xiaoming Ni, Xiaoming Ni, Xianliang Yi, Xianliang Yi, Xiaoming Ni, Xiaoming Ni, Yang Liu, Yang Liu, Yang Liu, Xianliang Yi, Yang Liu, Xianliang Yi, Yang Liu, Xianliang Yi, Hao Zhou Yang Liu, Yang Liu, Yang Liu, Hao Zhou Yang Liu, Yang Liu, Yang Liu, Hao Zhou Hao Zhou Yang Liu, Hao Zhou Qian Meng, Xianliang Yi, Xianliang Yi, Yang Liu, Yang Liu, Yang Liu, Hao Zhou Yang Liu, Hongyu Song, Yang Liu, Jingjing Zhan, Xiaoming Ni, Xianliang Yi, Xiaoming Ni, Jingjing Zhan, Yang Liu, Hao Zhou Xianliang Yi, Jingjing Zhan, Hao Zhou Hao Zhou Yang Liu, Hao Zhou Xiaoming Ni, Qian Meng, Hao Zhou Yang Liu, Xianliang Yi, Xiaoming Ni, Xiaoming Ni, Xiaoming Ni, Yang Liu, Jingjing Zhan, Yang Liu, Hao Zhou Yang Liu, Xianliang Yi, Hao Zhou Yang Liu, Yang Liu, Jingjing Zhan, Jingjing Zhan, Hongyu Song, Xianliang Yi, Jingjing Zhan, Yang Liu, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Jingjing Zhan, Xianliang Yi, Jingjing Zhan, Yang Liu, Yang Liu, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Jingjing Zhan, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Xianliang Yi, Hao Zhou Hao Zhou

Summary

Researchers exposed Chinese mitten crabs to tire wear particles (TWPs) and their leachate, finding that while TWPs accumulated in liver, gill, and gut tissues, toxicity was sublethal — disrupting antioxidant defenses and energy metabolism at higher doses — and that TWPs and their leachate act through partially distinct molecular mechanisms.

Tire wear particles (TWPs) were considered as an important component of microplastic pollution in the aquatic environment. To understand the ecotoxicity of TWPs to crustacean, this study investigated toxic effects of TWPs and the leachate on the mitten crab Eriocheir sinensis and the accumulation of TWPs in the crabs. Although TWPs could be accumulated in various tissues (i.e., liver, gills and gut) of the crabs, exposure to TWPs or the leachate had no lethal effect on the crabs in this study. Lower concentrations of TWPs and the leachate exposure could stimulate the antioxidant defense system of the crabs, while higher concentrations could disrupt the stress defense system. In addition, the energy supply and metabolism of the crabs could also be affected by TWPs or the leachate. The transcriptomic profiles showed that the toxic mechanisms of TWPs and the leachate were not exactly the same. Similar to the results of biochemical analysis, several Gene Ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to oxidative stress and energy metabolism were significantly regulated by both TWPs and the leachate. However, TWPs could affect the expression of genes enriched in immune-related pathways, while the leachate regulated the enrichment of some other signaling pathways including FoxO signaling pathway, insulin signaling pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway, PPAR signaling pathway and neuroactive ligand-receptor interaction. Overall, our study could provide basic biological information for assessing the ecological risk of the TWP pollution in the aquatic environment and was useful to understand the potential toxic mechanisms of the TWPs and the leachate to crustaceans.

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