P17-20: A conceptual model framework for the biodistribution of microplastics in the human body by using the Physiologically Based Pharmacokinetic (PBPK) model approach

The distribution of nano- and microplastics in the human body: a Hybrid Perfusion-Diffusion based PBK model

A Hybrid Perfusion-Diffusion based PBK model for the distribution of nano- and microplastics in the human body

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Researchers developed a hybrid perfusion-diffusion physiologically based kinetic model to predict the distribution of nano- and microplastics in the human body across tissues and organs, addressing a key gap in human health risk assessment. The PBK model framework enables estimation of internal plastic particle doses in specific organs from external exposure data, supporting more mechanistic risk assessments.

A Hybrid Perfusion-Diffusion based PBK model for the distribution of nano- and microplastics in the human body

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Researchers developed a hybrid physiologically-based kinetic model to predict the distribution of nano- and microplastic particles in the human body after ingestion. The model integrates perfusion and diffusion processes to estimate tissue-specific particle concentrations across different exposure scenarios.

Microplastic Pollution: Human Exposure, Uptake, Accumulation Pathways, and Potential Health Consequences

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Researchers reviewed the exposure routes, uptake mechanisms, and accumulation pathways of microplastics in the human body, concluding that the ubiquitous presence of these particles warrants urgent investigation into their long-term ecological and health consequences.

Pathways of human exposure to microplastics, and estimation of the total burden

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Tiny plastic bits called microplastics are everywhere, in the air we breathe, the food we eat, and even things that touch our skin, and this review pulls together existing research to show we're exposed through all three routes, not just by eating contaminated food like most studies focus on. The bigger takeaway: scientists still don't have standardized, reliable ways to measure exactly how much plastic ends up in our bodies, so the true scale of our exposure remains uncertain. This matters because until better testing methods exist, it's hard to know just how much plastic we're really taking in, or what it's doing to our health.