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TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
Summary
This review summarizes research on the TGF-beta signaling pathway and its roles in aging and immune function, using findings from studies in the roundworm C. elegans. Researchers found that this signaling pathway helps regulate lifespan, stress responses, and defense against pathogens. The study highlights how discoveries in this simple model organism continue to reveal fundamental biological mechanisms relevant to understanding aging and immunity across species.
The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical roles in development, differentiation, homeostasis, and disease. Due to the conservation of these ligands and their signaling pathways, genetic studies in invertebrate systems including the nematode Caenorhabditis elegans have been instrumental in identifying signaling mechanisms. C. elegans is also a premier organism for research in longevity and healthy aging. Here we summarize current knowledge on the roles of TGF-β signaling in aging and immunity.