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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics

American Journal of Industrial Medicine 2023 37 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Gregory M. Zarus, Custódio Muianga, Stephan Brenner, Katie Stallings, Gaston Casillas, Hana R. Pohl, Moiz Mumtaz, Kimberly Gehle

Summary

This study reviews evidence from workers in polyvinyl chloride (PVC) manufacturing plants and finds that PVC microplastic exposure is uniquely linked to liver cancer risk. The evidence of liver damage from occupational exposure to other types of microplastics is limited, suggesting PVC may be especially harmful. These worker studies provide important real-world data on how chronic microplastic exposure at high levels could affect human liver health.

Polymers
PVC
Body Systems
Hepatic

The data supporting liver toxicity are strongest for PVC exposure. Overall, the evidence of liver toxicity from occupational exposure to MPs other than PVC is lacking. The PVC worker data summarized here can be useful in assisting clinicians evaluating exposure histories from PVC exposure and designing future cell, animal, and population exposure-effect research studies.

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