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Membrane Biology of Non-Degradable Stress (MBNDS)
Summary
This study introduces Membrane Biology of Non-Degradable Stress (MBNDS), an interdisciplinary framework examining how biological membranes respond to entities like nanoplastics that cannot be enzymatically degraded or metabolically processed. The framework identifies the membrane interface as the primary site of conflict and proposes adaptive membrane dynamics as a key axis of cellular stress response.
Abstract Membrane Biology of Non-Degradable Stress is an interdisciplinary conceptual framework that examines living systems through the physical stability and adaptive dynamics of biological membrane boundaries when exposed to entities that cannot be biologically processed, enzymatically degraded, or metabolically integrated, such as nanoplastics and other inert nanoparticles. The framework posits that, under these conditions, the primary site of conflict is the membrane interface itself, and that the dominant mechanism of damage is persistent physical destabilization of the boundary rather than classical toxicological, infectious, or molecular-specific interactions. Downstream biological phenomena—including inflammation, mitochondrial dysfunction, and altered extracellular vesicle signaling—are interpreted as secondary consequences of a non-terminating boundary stress lacking a biological resolution state.