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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Reproductive & Development Sign in to save

A short-term high-fat diet alters rat testicular activity and blood-testis barrier integrity through the SIRT1/NRF2/MAPKs signaling pathways

Frontiers in Endocrinology 2023 18 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Sara Falvo, Sergio Minucci, Alessandra Santillo, Rosalba Senese, Gabriella Chieffi Baccari, Massimo Venditti

Summary

Researchers found that a short-term high-fat diet in rats caused changes in testicular function and disrupted the blood-testis barrier through specific cell signaling pathways. The study suggests that even moderate metabolic stress from overweight conditions can affect male reproductive health at the molecular level. The findings may help identify potential targets for preventing fertility issues related to metabolic disorders.

Body Systems
Reproductive
Models
Rat

The combined data led us to confirm that overweight is a less severe state than obesity. Furthermore, understanding the molecular mechanisms behind the association between metabolic disorders and male fertility could improve the possibility of identifying novel targets to prevent and treat fertility disorders related to overweight/obesity.

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