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Integrating transcriptomics and biochemical analysis to understand the interactive mechanisms of the coexisting exposure of nanoplastics and erythromycin on Chlorella pyrenoidosa
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Researchers used transcriptomics and biochemical analysis to study how nanoplastics and the antibiotic erythromycin interact when both are present in water with the green alga Chlorella pyrenoidosa. They found that the combined toxicity was dynamic, shifting from synergistic to antagonistic effects depending on nanoplastic concentration and exposure duration. The study indicates that co-exposure disrupts algal cell membranes, induces oxidative stress, and reduces photosynthetic efficiency.
Nanoplastics and antibiotics frequently co-exist in water polluted by algal blooms, but little information is available about interaction between substances. Erythromycin, as a representative of antibiotics, has been frequently detected in aquatic environments. This investigation attempted to reveal the interaction mechanism of nanoplastics and erythromycin on Chlorella pyrenoidosa. Results demonstrated that the joint toxicity of erythromycin and nanoplastics was dynamic and depended on nanoplastics concentration. Antagonistic effects of 1/2 or 1 EC erythromycin and nanoplastic concentration (10 mg/L) on the growth of C. pyrenoidosa was observed. The joint toxicity of 1/2 or 1 EC erythromycin and nanoplastic concentration (50 mg/L) was initially synergistic during 24-48 h and then turned to antagonistic during 72-96 h. Consequently, antagonistic effect was the endpoint for joint toxicity. Integration of transcriptomics and physiological biochemical analysis indicated that the co-existence of nanoplastics and erythromycin affected the signal transduction and molecular transport of algal cell membrane, induced intracellular oxidative stress, and hindered photosynthetic efficiency. Overall, this study provided a theoretical basis for evaluating the interactive mechanisms of nanoplastics and antibiotics.
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Researchers studied the chronic effects of nanoplastics on a freshwater microalga and found a surprising dual response: growth was initially inhibited during the first two weeks but then promoted at lower concentrations over longer exposure. Gene expression analysis revealed that the initial toxicity stemmed from suppressed protein synthesis, while the later recovery involved the algae ramping up cell division and stress defense mechanisms. The study provides molecular-level insights into how aquatic microorganisms may adapt to ongoing nanoplastic exposure.
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