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The potential impacts of micro-and-nano plastics on various organ systems in humans
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This review summarizes research on how micro- and nanoplastics can affect virtually every organ system in the human body, including the digestive, respiratory, immune, and reproductive systems. The evidence from animal and cell studies shows these particles cause harm through oxidative stress, inflammation, immune dysfunction, and disrupted metabolism, though more research using realistic exposure levels in humans is needed.
Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet fully understood. This review aims to provide an overview of the potential impacts of MNPs on various organ systems and identify knowledge gaps in current research. The summarized results suggest that exposure to MNPs can lead to health effects through oxidative stress, inflammation, immune dysfunction, altered biochemical and energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal organ development, and carcinogenicity. There is limited human data on the health effects of MNPs, despite evidence from animal and cellular studies. Most of the published research has focused on specific types of MNPs to assess their toxicity, while other types of plastic particles commonly found in the environment remain unstudied. Future studies should investigate MNPs exposure by considering realistic concentrations, dose-dependent effects, individual susceptibility, and confounding factors.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.