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Effects of exposure to nano-plastic drinking during pregnancy on cognitive related proteins in offspring of SD rats

Environmental Pollutants and Bioavailability 2023 12 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Jiang Chen, Huanliang Liu, Huanliang Liu, Huanliang Liu, Jiang Chen, Huanliang Liu, Huanliang Liu, Huanliang Liu, Huanliang Liu, Licheng Yan, Huanliang Liu, Ya‐Ping Zhang, Jiang Chen, Huanliang Liu, Huanliang Liu, Yue Shi, Jiang Chen, Jiang Chen, Bencheng Lin Bencheng Lin, Xuan Liu, Xuan Liu, Bencheng Lin Xuan Liu, Kang Li, Zhuge Xi, Bencheng Lin, Lei Tian, Wenqing Lai, Huanliang Liu, Wenqing Lai, Huanliang Liu, Wenqing Lai, Yue Shi, Xuan Liu, Zhuge Xi, Wenqing Lai, Huanliang Liu, Zhuge Xi, Yue Shi, Kang Li, Kang Li, Wenqing Lai, Zhuge Xi, Zhuge Xi, Zhuge Xi, Wenqing Lai, Bencheng Lin Zhuge Xi, Huanliang Liu, Yue Shi, Zhuge Xi, Huanliang Liu, Bencheng Lin, Licheng Yan, Bencheng Lin Wenqing Lai, Zhuge Xi, Zhuge Xi, Bencheng Lin, Wenqing Lai, Bencheng Lin Zhuge Xi, Lei Tian, Lei Tian, Bencheng Lin, Bencheng Lin Bencheng Lin Bencheng Lin Bencheng Lin, Bencheng Lin, Bencheng Lin Bencheng Lin Bencheng Lin

Summary

Researchers exposed pregnant rats to nanoplastics and then analyzed protein expression in the hippocampus of their offspring. They found reduced levels of proteins important for neural development and increased levels of inhibitory proteins, with pathway analysis highlighting ferroptosis as a key mechanism. The study suggests that prenatal nanoplastic exposure may contribute to cognitive deficits in offspring by disrupting brain protein expression during development.

Body Systems

Nervous Reproductive

Models

Rat

Nanoplastics, an emerging contaminant, pose risks to fetal neural development, transferring from mother to offspring via placenta and breast milk. Assessing these risks, hippocampal CA3 samples from nanopolystyrene-exposed rat offspring were proteomically analyzed. Findings revealed reduced expression of neural developmental proteins (KIF21A, STMN2, DMTN, DLG1) and increased inhibitory proteins (PZP, α-2M, FN1, SERPINA1, ALOX15) in the hippocampus. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted ferroptosis enrichment, validated by significantly expressed ALOX15 and TF proteins. These alterations suggest nanopolystyrene’s potential contribution to cognitive deficits and neurodevelopmental disorders, emphasizing its hazardous impact on neural development. This study provides novel insights into nanopolystyrene’s risks.

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