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Quantitative analysis of microplastics and nanoplastics released from disposable PVC infusion tubes
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Researchers measured the micro and nanoplastics released from brand-new disposable PVC infusion tubes used in hospitals, finding that each tube carries nearly 1,000 microplastic particles before any fluid even passes through. When infusion fluids were run through the tubes, they picked up additional particles, with the amount increasing at higher temperatures and longer durations. This means patients receiving IV fluids may be exposed to PVC plastic particles that enter directly into their bloodstream.
The exposure of micro- and nanoplastics (MNPs) via medical device is still unknown to us. Herein, a visual quantitative detection of polyvinyl chloride (PVC) MPs and a fluorescent quantitative detection of PVC NPs were developed. To overcome the aggregation of PVC NPs, sodium dodecylbenzene sulfonate was used as the stabilizer of PVC NPs. The brand-new disposable PVC infusion tubes were found to carry PVC MPs with the average total number (ATN) of 931.4 particles and PVC NPs with the average mass of 0.040 μg, respectively. For four typical infusion fluids such as 0.9% sodium chloride, 5% glucose, 5% sodium bicarbonate, hydroxyethyl starch 40 sodium chloride, the released PVC MPs and NPs were ranged from 1003.6 ∼ 3494.6 particles and 0.042 ∼ 0.087 μg, respectively in stimulating normal infusion scenario (room temperature 4 h). The released PVC MPs and NPs were also increased with the infusion duration and temperature. The released PVC MPs are mainly in granular form, accounting for 38 ∼ 49% of the total PVC MPs. Our findings indicate PVC MNPs can enter the blood vessel directly with the infusion fluids during intravenous infusion and the PVC MNPs exposure risk towards patients deserves more attention.
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