Neuroendocrine Pathway-Mediated Neurotoxicity to Nanoplastics with Different Surface Functional Groups on Zebrafish (Danio Rerio) at Early Life Stage

Nanoplastics disrupt Thyroid Hormone Homeostasis and Neurodevelopment in Zebrafish: A Systems-Level Assessment

Simulated Environmental Nanoplastics Induce Zebrafish Developmental Toxicity and Stress Response

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Scientists exposed zebrafish embryos to nanoplastics that were specially broken down to mimic how plastic actually degrades in oceans and rivers, and found they caused more harm than the lab-made plastic beads typically used in research, stunting growth, slowing hatching, and triggering stress hormone spikes even at very low doses. Because these effects showed up at concentrations similar to what's found in real water sources, the findings suggest current safety testing may be underestimating the risks nanoplastics pose to both aquatic life and, potentially, to people who drink that water or eat seafood from it.

Bioaccumulation and Toxic Effects of Micro- and Nanoplastics in Zebrafish: A Critical Review

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Researchers comprehensively reviewed micro- and nanoplastic bioaccumulation and toxicity in zebrafish, finding that these particles accumulate in digestive organs, gills, liver, and brain, inducing oxidative stress, developmental delays, neurotoxicity, and transgenerational reproductive impairments that highlight broad ecological risks.

Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish

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This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.

Toxicity and behavioral response of zebrafish exposed to combined microplastic and bisphenol analogues

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Co-exposure of zebrafish larvae to polystyrene microplastics combined with bisphenol A or F increased larval lethality by 7–51% compared to either pollutant alone, while also causing stronger behavioral effects including reduced movement and activity. This synergistic toxicity — not seen in embryos — highlights the danger of treating microplastics and chemical contaminants as independent hazards, since real-world exposures are always mixed.