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Effects of Novel Biodegradable Polyglycolic Acid (Pga) Microplastics on Systemic Toxicity of the Gut-Liver-Brain Axis in Zebrafish
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Zebrafish exposed to polyglycolic acid (PGA) microplastics, a type of biodegradable plastic used in medical devices and food packaging, showed damage across the gut, liver, and brain through the gut-liver-brain axis. The microplastics increased gut permeability, disrupted beneficial gut bacteria, interfered with liver fat metabolism, and caused anxiety-like behavior and cognitive impairment. This study is notable because it shows that even biodegradable plastics can cause significant toxic effects when they break down into microplastics.
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