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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Marine & Wildlife Nanoplastics Reproductive & Development Sign in to save

Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Environmental Science Nano 2024 5 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Dongzhi Gou, Jiao-Yun Deng, Qi-Ping Tang, Jiajia Lu, Li Bao, Yiyun Liu, De‐Sheng Pei

Summary

This study demonstrated that nanoplastics disrupt early embryonic development and impair mitochondrial function in zebrafish by inhibiting PINK1/Parkin-mediated mitophagy, a cellular cleanup process. A mitophagy activator was able to mitigate these effects, pointing to mitochondrial dysfunction as a key mechanism of nanoplastic hematological and circulatory toxicity.

Body Systems
Hematopoietic
Models
Zebrafish

This study demonstrates that nanoplastics disrupt early embryonic development, impair mitochondrial function, and inhibit PINK1/Parkin-mediated mitophagy, which can be mitigated with a mitophagy activator.

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