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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Marine & Wildlife Nanoplastics Reproductive & Development Sign in to save

Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Environmental Science Nano 2024 5 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei Dongzhi Gou, Dongzhi Gou, Yiyun Liu, Jiao-Yun Deng, Qi-Ping Tang, Jiao-Yun Deng, De‐Sheng Pei Jiao-Yun Deng, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei Dongzhi Gou, De‐Sheng Pei Qi-Ping Tang, Jiao-Yun Deng, Qi-Ping Tang, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei Yiyun Liu, Qi-Ping Tang, Qi-Ping Tang, Li Bao, Qi-Ping Tang, Li Bao, Jiajia Lu, Jiajia Lu, Jiajia Lu, Jiajia Lu, De‐Sheng Pei Li Bao, De‐Sheng Pei Li Bao, De‐Sheng Pei De‐Sheng Pei Yiyun Liu, Li Bao, Li Bao, De‐Sheng Pei Yiyun Liu, Yiyun Liu, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei

Summary

This study demonstrated that nanoplastics disrupt early embryonic development and impair mitochondrial function in zebrafish by inhibiting PINK1/Parkin-mediated mitophagy, a cellular cleanup process. A mitophagy activator was able to mitigate these effects, pointing to mitochondrial dysfunction as a key mechanism of nanoplastic hematological and circulatory toxicity.

Body Systems
Hematopoietic
Models
Zebrafish

This study demonstrates that nanoplastics disrupt early embryonic development, impair mitochondrial function, and inhibit PINK1/Parkin-mediated mitophagy, which can be mitigated with a mitophagy activator.

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