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Knockdown of LCN2 Attenuates Brain Injury After Intracerebral Hemorrhage via Suppressing Pyroptosis
Summary
Researchers found that reducing levels of a protein called lipocalin-2 (LCN2) in the brain lessened injury severity after intracerebral hemorrhage in animal models. The protective effect was linked to suppression of pyroptosis, a form of inflammatory cell death. The study suggests that targeting LCN2 could be a potential strategy for reducing brain damage following hemorrhagic stroke.
Inhibition of LCN2 attenuates brain injury after ICH via suppressing pyroptosis, which provide guidance for ICH management.
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