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A bibliometric landscape of polyhydroxyalkanoates production from low-cost substrates by Cupriavidus necator and its perspectives for the Latin American bioeconomy
Summary
This bibliometric analysis examined research on polyhydroxyalkanoate (PHA) biopolymer production by the model bacterium Cupriavidus necator using low-cost substrates, reviewing the field's relevance to the Latin American bioeconomy. Cupriavidus necator can accumulate PHAs up to 90% of dry cell weight, making it a key organism for developing biodegradable alternatives to petroleum-based plastics.
The replacement of petroleum-based plastics with biodegradable materials emerges as a potential solution to the environmental issues caused by the constant consumption of non-degradable plastic materials.Polyhydroxyalkanoates (PHA) are natural biopolymers produced by several bacteria species as an evolutive mechanism to store carbon and energy.Among these PHA-producing bacteria, the Gram-negative bacterium Cupriavidus necator has been studied as the model organism for PHA production due to its high accumulation capacity (up to 90% of dry cell weight).Nevertheless, the large-scale production of those biopolymers is still limited by the production costs, especially regarding the carbon source, which may represent up to 50% of the total cost of the PHA production process.For this study, a bibliometric analysis was conducted to investigate the trends in PHA production studies by C. necator with an emphasis on the use of low-cost substrates, in addition to the perspectives for this emerging industry in Latin America as a continent with access to significant biomass resources, agroindustry products, and byproducts.The Scopus and the Web of Science databases were used for data collection, and a total of 532 and 2995 articles were identified for the period between 1992 and 2022, and between 2000 and 2022, respectively. ARTICLE HIGHLIGHTS •Bibliometric analysis of PHA production from low-cost substrates by C. necator was carried out. •Potential and available biomasses in LATAM are reported for PHA production. •The most commonly low-cost carbon sources used to production of PHA by C. necator are waste oils and fats, sugar-rich residues, and derivatives.
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