From In Vivo to In Vitro: An Intriguing Journey of Fish Cell lines

Cell culture techniques have largely replaced the traditional protocols for efficient and precise research.In fisheries sciences, research based on the development and application of fish cell lines has become popular over a period of two decades.Fish cell lines find wide application in the development of vaccines, toxicological studies, drug development, and biotechnological manipulations that have set new landmark.The use of fish cell lines is thought to be one of the best alternatives for the studies carried on fishes, because the cell lines have the host's cellular genetic homogeneity and have low variability.The available articles for finfish cell lines were used to examine worldwide distribution.The cell lines have been observed an emerging research topic to have an important role in identification and prevention of viral and bacterial diseases, evaluation of treatment options and proactive management strategies that are critical for optimal fish health management.This review briefs the trend of development and potential use of fish cell lines in advanced research in the fisheries sector.Genomic methods implied for early disease diagnosis, isolation of new pathogens, identification of toxicity mechanism, early attainment of growth and, maturity by fish in culture systems and conservation of threatened/endangered fish species is the propensity of cell line development.