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“Reproductive and Transgenerational Toxicity of Micro- and Nanoplastics: A Systematic Review and Meta-Analysis”
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This meta-analysis pools data from multiple animal studies to assess how micro- and nanoplastics affect reproduction and the health of future generations. The research looks at whether plastic particle exposure can harm fertility, pregnancy outcomes, and offspring development in lab animals. These findings are important because they suggest microplastic exposure could have effects that extend beyond the individual to their children.
This project aims to systematically review and meta-analyze the effects of micro- and nanoplastics on reproductive and generational outcomes in experimental animal models.
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The effects of exposure to microplastics on female reproductive health and pregnancy outcomes: A systematic review and meta-analysis
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This meta-analysis pools data from multiple studies to assess how microplastic exposure affects female reproductive health and pregnancy outcomes. The findings suggest that microplastic accumulation may be linked to adverse effects on fertility and pregnancy, highlighting an important and underexplored area of concern for women's health.
The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes
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This review examines how microplastics and nanoplastics can accumulate in reproductive organs and harm fertility in both males and females. In animal studies, exposure led to damaged sperm, disrupted hormones, and abnormal ovary and uterus structure. Offspring of exposed mothers also showed metabolic problems, immune issues, and cognitive disorders, suggesting these particles may affect future generations.
Reproductive toxicity and transgenerational effects of microplastics: Evidence from experimental models and underlying epigenetic mechanisms
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Tiny plastic particles have been found in human reproductive fluids, and this review of animal research shows they can harm fertility in both sexes and may even affect the health of future children and grandchildren—not just people directly exposed. Scientists think microplastics may cause these lasting effects by altering "chemical switches" on DNA that get passed down through generations, changing how genes turn on and off without changing the DNA itself. While the animal evidence is concerning, more human studies are needed to confirm these effects happen the same way in people.
Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications
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This review summarizes existing research on how nanoplastics (tiny plastic particles smaller than one micrometer) affect reproductive health in animals and potentially humans. Studies show that nanoplastics can accumulate in reproductive organs including the placenta, and evidence from animal studies links exposure to hormone disruption, reduced fertility, and developmental problems. The authors highlight a significant knowledge gap about nanoplastic effects on human reproduction, despite growing evidence that these particles reach our reproductive systems.
Micro-nanoplastics pollution and mammalian fertility: A systematic review and meta-analysis
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This meta-analysis of 79 studies across five mammalian species found that micro- and nanoplastics cause reproductive toxicity in a concentration-dependent manner, particularly at high doses. Polystyrene was the most studied polymer, and most research focused on male fertility in mice, leaving a significant gap in knowledge about effects on food-producing animals that could serve as vectors for human exposure.
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