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Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry

Particle and Fibre Toxicology 2024 23 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Denisa Lizoňová, Denisa Lizoňová, Amogh Nagarkar, Amogh Nagarkar, Philip Demokritou Philip Demokritou Georgios A. Kelesidis, Georgios A. Kelesidis, Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou Philip Demokritou

Summary

This study shows that the way inhaled nanoparticles clump together changes their actual density, which in turn affects how deeply they deposit in the lungs. Current lung dosimetry models overestimate exposure by using bulk material density instead of the real effective density of airborne particle clusters. Getting this measurement right is essential for accurately assessing the health risks of inhaling nanoparticles, including nanoplastics.

Body Systems

Respiratory

The doses of inhaled NPs are overestimated by inhalation particle deposition models when the ρ<sub>b</sub> is used instead of the real-world effective density which can vary significantly due to the porous agglomerate structure of NPs. So the use of realistic ρ<sub>eff</sub>, which can be measured as described here, is essential to determine the lung deposition and dosimetry of inhaled NPs and their impact on public health.

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