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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Reproductive & Development Sign in to save

MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice

Journal of Translational Medicine 2024 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Yining Liu, Tongtong Li, Tongtong Li, Mingze Shi, Tongtong Li, Mingze Shi, Yanling Wan, Yanling Wan, Hanzhen Li, Hanzhen Li, Tongtong Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lü, Gang Lü, Hongbin Liu, Haobo Zhang, Tao Huang

Summary

Researchers identified a protein called MORN2 that plays a critical role in shaping mitochondria and supporting their energy production in sperm cells. When this protein was absent in mice, the animals became infertile due to defective mitochondrial structures in their sperm. The study adds to our understanding of the molecular requirements for male reproductive health.

Our study demonstrates that MORN2 is essential for male fertility and indicates that MORN2 functions in mitochondrial sheath formation and regulates mitochondrial respiratory activity.

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