Farm animals as a critical link between environmental and human health impacts of micro-and nanoplastics

Abstract Plastic pollution is an increasing global health concern, particularly the ever-increasing amount of tiny plastic particles commonly referred to as micro- and nanoplastics (MNPs). Most research to date on MNP exposure and hazards has focused on environmental species such as aquatic organisms and, more recently, humans, leaving impacts on farm animals largely unstudied. MNPs have been detected in all environmental compartments, including agricultural environments, farm animals and food products originating from them. The health of farm animals can be directly affected by MNPs, while humans can be affected by MNPs present in animal-derived food products. In this perspective article, we argue that MNP research should give more attention to farm animals forming a critical link between the environment and human health. Here, we summarize evidence on sources, exposure routes, levels in farm animals, and potential health effects of MNPs on farm animals, and identify knowledge gaps for future research, such as effects of MNPs on reproduction and development. In particular, the bovine embryo model is a promising model to study effects of MNPs on early development of both farm animals and humans. This perspective article signals the need for follow up studies that will increase our understanding of the transfer of MNPs between environment, farm animals, and humans, and the potential of farm animals to serve as an indicator for other animals, including humans.