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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Respiratory Research 2024 6 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yuan‐Ting Hsu, Chao‐Chien Wu, Chin‐Chou Wang, Chau‐Chyun Sheu, Yi‐Hsin Yang, Ming−Yen Cheng, Ruay-Sheng Lai, Sum‐Yee Leung, Chi-Cheng Lin, Yufeng Wei, Yung‐Fa Lai, Meng‐Hsuan Cheng, Huang‐Chi Chen, Chih‐Jen Yang, Chien‐Jen Wang, Huei‐Ju Liu, Hua‐Ling Chen, Chih‐Hsing Hung, Chon‐Lin Lee, Ming-Shyan Huang, Shau‐Ku Huang

Summary

Researchers analyzed data linking urinary metabolites of DEHP — a phthalate plasticizer (a chemical added to plastics to make them flexible) found in food packaging, medical devices, and household products — to asthma risk, finding that certain asthma subtypes showed heightened vulnerability to these exposures. The results suggest DEHP metabolites may affect immune pathways in asthma through mechanisms distinct from classic inflammatory responses.

Body Systems
Immune
Models
Human

The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.

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