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Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters
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Researchers analyzed data linking urinary metabolites of DEHP — a phthalate plasticizer (a chemical added to plastics to make them flexible) found in food packaging, medical devices, and household products — to asthma risk, finding that certain asthma subtypes showed heightened vulnerability to these exposures. The results suggest DEHP metabolites may affect immune pathways in asthma through mechanisms distinct from classic inflammatory responses.
The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.
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Pilot study: Unveiling the impact of bisphenol A and phthalate exposure on women with asthma
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This study examined microplastic ingestion in commercially important cephalopods from the North Atlantic. Plastic particles were identified in the digestive glands of a high proportion of individuals, indicating that microplastic contamination extends to deep-sea and open-ocean food webs.
Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway
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This mouse study found that polystyrene microplastics combined with DEHP, a common plastic additive, worsened allergic asthma symptoms more than either pollutant alone. The combination activated an inflammatory pathway called TRPA1-p38 MAPK in lung tissue, increasing airway inflammation and mucus production. The findings suggest that real-world exposure to microplastics carrying chemical additives could aggravate respiratory conditions like asthma.
Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma
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Chemicals that mimic estrogen, like BPA and BPS found in plastics, may change the way immune cells behave at a molecular level, potentially making kids more prone to developing asthma. In lab tests on human immune cells, these estrogen-like compounds altered key signaling pathways that control immune function, suggesting one way everyday exposure to plastics-related chemicals could contribute to rising asthma rates. While this early research was done in cells rather than in people, it adds to concerns about how common chemical exposures might shape our children's health.
Di-(2-ethylhexyl) phthalate and its metabolites research trend: a bibliometric analysis
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This bibliometric analysis mapped research trends on di-(2-ethylhexyl) phthalate (DEHP) and its metabolites, identifying growth areas, major contributors, and gaps in understanding human exposure, metabolism, and health effects of this common plasticizer.
Machine learning identifies molecular targets of Di (2-ethylhexyl) phthalate in pulmonary arterial hypertension
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Researchers combined genomic differential expression analysis with machine learning and network toxicology to identify 12 core genes through which the plasticizer DEHP may drive pulmonary arterial hypertension, with the identified genes involved in pathways regulating vascular remodeling and cellular stress response.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.