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Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production
Summary
This review covers how the fungus Aspergillus oryzae is being engineered as a biological factory for producing industrial enzymes and useful chemicals. While not about microplastics directly, engineered fungi like A. oryzae are being explored as potential tools for breaking down plastic waste through biological degradation. Advances in engineering these organisms could eventually contribute to reducing microplastic pollution in the environment.
Aspergillus oryzae, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits a robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as a cell factory for industrial enzyme production. Moreover, A. oryzae has the ability to synthesize various secondary metabolites, such as kojic acid and L-malic acid. Nevertheless, the complex secretion system and protein expression regulation mechanism of A. oryzae pose challenges for expressing numerous heterologous products. By leveraging synthetic biology and novel genetic engineering techniques, A. oryzae has emerged as an ideal candidate for constructing cell factories. In this review, we provide an overview of the latest advancements in the application of A. oryzae-based cell factories in industrial production. These studies suggest that metabolic engineering and optimization of protein expression regulation are key elements in realizing the widespread industrial application of A. oryzae cell factories. It is anticipated that this review will pave the way for more effective approaches and research avenues in the future implementation of A. oryzae cell factories in industrial production.
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