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Hormônios Esteroides E a Influência Do Bisfenol-a
Summary
This review examines the impact of bisphenol-A (BPA), a substance found in plastics, on steroid hormone metabolism based on articles from Scielo and PubMed published between 2016 and 2023. The review finds that BPA disrupts estrogen receptor signaling across reproductive and nervous system tissues through estrogenic and oxidative/pro-apoptotic mechanisms, and that despite its short half-life, continuous exposure leads to accumulation detectable in blood and urine.
Este trabalho tem como objetivo relatar o impacto do bisfenol-A (BPA) no organismo considerando seus principais malefcios causados por sua alta exposio e a consequente interferncia nos hormnios esteroides, sobretudo o estradiol. O mtodo constitui-se em reviso bibliogrfica descritiva e qualitativa, analisando artigos das plataformas Scielo e PubMed publicados entre 2016 e 2023. O BPA uma substncia encontrada no plstico, que provoca a desregulao do metabolismo dos hormnios esteroides ao se ligar nos receptores estrognicos (ER), presentes em diferentes tecidos de vrios sistemas do corpo, como no sistema reprodutor e no sistema nervoso. Atravs de sua ao estrognica e/ou oxidativa/pr-apopttica, pode ser considerado neurotxico e obesognico, alm de desregular funes reprodutoras. Apesar do BPA ter meia-vida curta e ser excretado pelo organismo, a exposio contnua resulta em acmulo sendo encontrado inclusive no sangue e na urina. Portanto, o consumo de plstico deve ser diminudo, a fim de evitar a contaminao exacerbada por bisfenol e outras substncias potencialmente nocivas.
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