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Hormônios Esteroides E a Influência Do Bisfenol-a
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This review examines the impact of bisphenol-A (BPA), a substance found in plastics, on steroid hormone metabolism based on articles from Scielo and PubMed published between 2016 and 2023. The review finds that BPA disrupts estrogen receptor signaling across reproductive and nervous system tissues through estrogenic and oxidative/pro-apoptotic mechanisms, and that despite its short half-life, continuous exposure leads to accumulation detectable in blood and urine.
Este trabalho tem como objetivo relatar o impacto do bisfenol-A (BPA) no organismo considerando seus principais malefcios causados por sua alta exposio e a consequente interferncia nos hormnios esteroides, sobretudo o estradiol. O mtodo constitui-se em reviso bibliogrfica descritiva e qualitativa, analisando artigos das plataformas Scielo e PubMed publicados entre 2016 e 2023. O BPA uma substncia encontrada no plstico, que provoca a desregulao do metabolismo dos hormnios esteroides ao se ligar nos receptores estrognicos (ER), presentes em diferentes tecidos de vrios sistemas do corpo, como no sistema reprodutor e no sistema nervoso. Atravs de sua ao estrognica e/ou oxidativa/pr-apopttica, pode ser considerado neurotxico e obesognico, alm de desregular funes reprodutoras. Apesar do BPA ter meia-vida curta e ser excretado pelo organismo, a exposio contnua resulta em acmulo sendo encontrado inclusive no sangue e na urina. Portanto, o consumo de plstico deve ser diminudo, a fim de evitar a contaminao exacerbada por bisfenol e outras substncias potencialmente nocivas.
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This review synthesized evidence on bisphenol A (BPA) — a chemical used in polycarbonate plastics and epoxy resins — covering its sources of human exposure, endocrine-disrupting mechanisms, and associations with metabolic, reproductive, and developmental health outcomes.
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This review examined the effects of bisphenol A (BPA) leaching from polycarbonate plastics on blood parameters and fertility indicators, summarizing animal and human studies showing endocrine-disrupting effects. BPA exposure was associated with hormonal imbalances and impaired reproductive outcomes.
Systematic Review: Impact of Bisphenol-A (BPA) Exposure on Human Health
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This systematic review of 30 studies published between 2018 and 2024 found that bisphenol-A (BPA) exposure is associated with cancer, obesity, reproductive disruption, hypertension, and developmental and behavioral changes in children, with exposure occurring through food packaging, air, and dust.
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This study found that bisphenol A, F, and S all disrupt steroidogenesis in adrenocortical cells at non-cytotoxic concentrations in cell culture, producing compound-specific alterations in hormone levels, providing evidence that BPF and BPS are not necessarily safer endocrine alternatives to BPA.
Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
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This review examines the molecular mechanisms by which bisphenol A (BPA), a common endocrine-disrupting chemical found in plastics, may contribute to various health conditions. Researchers analyzed BPA's effects on mesenchymal stem cells and fat cell development, as well as its uses in dental, orthopedic, and industrial applications. The study suggests that BPA exposure can alter multiple molecular pathways involved in immune, metabolic, and cellular processes.
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