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Risk assessment of microplastics in metabolic stress and permeability-induced Caenorhabditis elegans models
Summary
Researchers used Caenorhabditis elegans models -- including healthy worms, high-glucose diet-induced metabolic disease models, and Pseudomonas aeruginosa-induced intestinal inflammation models -- to assess PE microplastic toxicity at 0.01-0.1 ug/mL, finding no significant toxicity in healthy or metabolic disease models but increased intestinal permeability and reactive oxygen species in the inflammation model.
우리는 건강한 예쁜꼬마선충과 고포도당 식이 및 녹농균에 의해 각각 대사질환 및 염증이 유도된 예쁜꼬마선충 질병모델을 이용하여 PE-MPs 노출에 의해 유도되는 생체 내 독성 차이에 대해 조사하였다. 0.01-0.1 μg/mL의 PE-MPs를 건강한 선충에게 섭취시킨 후 급성독성 및 행동변화를 확인한 결과, 선충의 생존율이나 움직임에 대하여 PE-MPs 노출군과 대조군 사이의 차이가 없음을 확인하였다. 다음으로 고포도당 식이로 대사질환이 유도된 선충과 건강한 선충 사이에서 미세플라스틱의 노출로 인한 생체 내 총 지질 및 활성산소종 발생에 대한 차이는 확인되지 않았다. 그러나 녹농균에 의해 장 내 염증이 유도된 선충과 건강한 선충 사이에서 미세플라스틱의 위해성을 확인한 결과, 녹농균에 의해 장 내 염증이 유도된 선충에서 미세플라스틱의 노출은 장투과성 및 활성산소종의 생성에 대조군보다 부정적인 영향을 미치는 것으로 확인하였다. 본 연구에서는 미세플라스틱의 노출이 건강한 모델에서 보다 질환이 유도된 모델에서 더 치명적일 수 있음을 시사하며, 특히 염증으로 인한 조직손상 모델에서 그 심각성이 더해질 수 있음을 의미한다.
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