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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Remediation Sign in to save

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

Frontiers in Immunology 2024 25 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Cameron R. Bishop, Kexin Yan, Wilson Nguyen, Daniel J. Rawle, Bing Tang, Thibaut Larcher, Andreas Suhrbier

Summary

This study found that microplastics can interfere with the immune response in lungs infected with SARS-CoV-2, the virus that causes COVID-19, by blocking a protein called Tim4 that helps clear dead cells. The findings suggest that microplastic exposure in the lungs could worsen respiratory infections by disrupting the body's ability to manage inflammation and clean up damaged tissue.

Body Systems
Immune Respiratory

The findings are consistent with the recent finding that MPs can inhibit phagocytosis of apoptotic cells via binding of Tim4. They also add to a growing body of literature suggesting that MPs can dysregulate inflammatory processes in specific disease settings.

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