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Synergy under the Sun? Nanoplastics Enhance Estrogenicity of Common UV-Blocker
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Human cells and zebrafish co-exposed to polystyrene nanoplastics and the UV filter homosalate showed higher plastic accumulation in tissues, greater estrogenic activity, and more pronounced gene expression changes than with either exposure alone.
Human cells and zebrafish coexposed to nanoplastics and the sunscreen ingredient homosalate showed more plastics in tissues, estrogenic activity, and relevant gene expression changes than they showed after either exposure alone.
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Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish
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Researchers found that tiny polystyrene nanoplastics can enhance the estrogen-mimicking effects of homosalate (a common sunscreen ingredient) in human breast cancer cells and zebrafish. The nanoplastics acted as carriers, increasing cellular uptake of the sunscreen chemical and amplifying its hormone-disrupting activity. This is significant for human health because people are regularly exposed to both nanoplastics and sunscreen chemicals simultaneously.
Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos
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Researchers found that polystyrene nanoplastics and the UV sunscreen chemical BM-DBM interact synergistically to cause neurotoxicity in zebrafish at environmentally relevant concentrations, disrupting nervous system development and gene expression more severely in combination than either pollutant alone.
Interactive transgenerational effects of polystyrene nanoplastics and ethylhexyl salicylate on zebrafish
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The combined transgenerational effects of polystyrene nanoplastics and the UV filter ethylhexyl salicylate (EHS) were studied in zebrafish across multiple generations. Nanoplastics affected the bioaccumulation and multigenerational toxicity of EHS, indicating that nanoplastics can modify chemical exposure outcomes across zebrafish generations.
Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate
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Researchers found that polystyrene nanoplastics affect the bioaccumulation and distribution of the UV filter ethylhexyl salicylate in zebrafish, and that nanoplastics facilitate the parental transfer of this chemical contaminant to offspring.
Endogenous 15(S)-hydroxyeicosatetraenoic acid mediates amplified estrogenic responses under nanoplastic–homosalate coexposure
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Researchers investigated how co-exposure to polystyrene nanoplastics and the UV filter homosalate amplifies estrogenic effects in mice and human cell models. The study identified endogenous 15(S)-HETE as a key mediator of these amplified responses, providing evidence for a mechanism behind the so-called Trojan horse effect where nanoplastics enhance the toxicity of co-occurring chemicals.
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