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Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier
Summary
This review examines the various experimental methods used to study how drugs and chemicals cross the placental barrier and reach the developing fetus. Understanding how contaminants including microplastics can pass from mother to baby is essential for protecting fetal health and developing safer guidelines for chemical exposure during pregnancy.
Research is being increasingly carried out to obtain an accurate and safe evaluation of drug and chemical transport and metabolism across the placental barrier, applying a combination of advanced techniques to avoid potential fetotoxic effects. The improvement of the currently available techniques and the development of novel experimental protocols and methodologies are of major importance to protect both the mother and the fetus from xenobiotic exposure, as well as to minimize potential fetotoxicity effects.
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