Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study (Preprint)
2024
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Juliette Legler,
Laurens D. B. Mandemaker,
Juliette Legler,
Zimmermann, Lisa,
Nelly D. Saenen,
Nelly D. Saenen,
Nelly D. Saenen,
Zimmermann, Lisa,
Nelly D. Saenen,
Jeske van Boxel,
Zimmermann, Lisa,
Zimmermann, Lisa,
Hanna M. Dusza,
Hanna M. Dusza,
Hanna M. Dusza,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Jane Muncke,
Zimmermann, Lisa,
Zimmermann, Lisa,
Laura M Zoutendijk,
Kuanliang Shao,
Anna R. Robuck,
Laurens D. B. Mandemaker,
Zimmermann, Lisa,
Jane Muncke,
Hanna M. Dusza,
Amanda Durkin,
Laura M Zoutendijk,
Amanda Durkin,
Amanda Durkin,
Jeske van Boxel,
Florian Meirer,
Barbara M. Scholz‐Böttcher,
Laurens D. B. Mandemaker,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Anna R. Robuck,
Matthew Boyles,
Juliette Legler,
Tim S. Nawrot,
Nelly D. Saenen,
Jeske van Boxel,
Jeske van Boxel,
Runyu Zou,
Runyu Zou,
Runyu Zou,
Zimmermann, Lisa,
Zimmermann, Lisa,
Barbara M. Scholz‐Böttcher,
Florian Meirer,
Florian Meirer,
Barbara M. Scholz‐Böttcher,
Justin M. Boucher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Hanna M. Dusza,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Majorie B.M. van Duursen,
Majorie B.M. van Duursen,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Juliette Legler,
Juliette Legler,
Juliette Legler,
Justin M. Boucher,
Florian Meirer,
Florian Meirer,
Matthew Boyles,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Laurens D. B. Mandemaker,
Laurens D. B. Mandemaker,
Runyu Zou,
Juliette Legler,
Petra Příbylová,
Petra Příbylová,
Justin M. Boucher,
Matthew Boyles,
Markus Forsberg,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Juliette Legler,
Majorie B.M. van Duursen,
Jeske van Boxel,
Jeske van Boxel,
Jeske van Boxel,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Virissa Lenters,
Justin M. Boucher,
Juliette Legler,
Justin M. Boucher,
Jane Muncke,
Jane Muncke,
Jane Muncke,
Hanna M. Dusza,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Juliette Legler,
Laurens D. B. Mandemaker,
Mariona Bustamante,
Mariona Bustamante,
Justin M. Boucher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Juliette Legler,
Douglas I. Walker,
Florian Meirer,
Juliette Legler,
Barbara M. Scholz‐Böttcher,
Roel Vermeulen
Runyu Zou,
Florian Meirer,
Tim S. Nawrot,
Florian Meirer,
Florian Meirer,
Barbara M. Scholz‐Böttcher,
Juliette Legler,
Majorie B.M. van Duursen,
Roel Vermeulen
Majorie B.M. van Duursen,
Emily A Christopher,
Runyu Zou,
Florian Meirer,
Jane Muncke,
Emily A Christopher,
Hanna M. Dusza,
Barbara M. Scholz‐Böttcher,
Roel Vermeulen
Justin M. Boucher,
Barbara M. Scholz‐Böttcher,
Petra Příbylová,
Petra Příbylová,
Roel Vermeulen
Barbara M. Scholz‐Böttcher,
Florian Meirer,
Florian Meirer,
Barbara M. Scholz‐Böttcher,
Payam Dadvand,
Juliette Legler,
Payam Dadvand,
Hanna M. Dusza,
Roel Vermeulen
Hanna M. Dusza,
Florian Meirer,
Florian Meirer,
Tim S. Nawrot,
Hanna M. Dusza,
Petra Příbylová,
Roel Vermeulen
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Majorie B.M. van Duursen,
Majorie B.M. van Duursen,
Markus Forsberg,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Tim S. Nawrot,
Petra Příbylová,
Markus Forsberg,
Justin M. Boucher,
Runyu Zou,
Roel Vermeulen
Karen S. Galea,
Karen S. Galea,
Nelly D. Saenen,
Juliette Legler,
Douglas I. Walker,
Juliette Legler,
Barbara M. Scholz‐Böttcher,
Petra Příbylová,
Laurens D. B. Mandemaker,
Laurens D. B. Mandemaker,
Jane Muncke,
Florian Meirer,
Florian Meirer,
Jane Muncke,
Runyu Zou,
Jane Muncke,
Tim S. Nawrot,
Zimmermann, Lisa,
Tim S. Nawrot,
Petra Příbylová,
Karen S. Galea,
Petra Příbylová,
Anna R. Robuck,
Roel Vermeulen
Anna R. Robuck,
Runyu Zou,
Runyu Zou,
Matthew Boyles,
Nelly D. Saenen,
Nelly D. Saenen,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Kuanliang Shao,
Kuanliang Shao,
Barbara M. Scholz‐Böttcher,
Barbara M. Scholz‐Böttcher,
Martine Vrijheid,
Martine Vrijheid,
Douglas I. Walker,
Douglas I. Walker,
Zimmermann, Lisa,
Zimmermann, Lisa,
Barbara M. Scholz‐Böttcher,
Laura M Zoutendijk,
Laura M Zoutendijk,
Laura M Zoutendijk,
Virissa Lenters,
Virissa Lenters,
Roel Vermeulen
Roel Vermeulen
Barbara M. Scholz‐Böttcher,
Jane Muncke,
Barbara M. Scholz‐Böttcher,
Roel Vermeulen
Summary
The AURORA project protocol describes an interdisciplinary European study investigating micro- and nanoplastic exposures and their biological effects during pregnancy and early life, enrolling mother-child cohorts and combining biomonitoring with mechanistic research. The project aims to identify critical windows of developmental vulnerability to plastic pollution.
<sec> <title>BACKGROUND</title> Micro- and nanoplastics (MNPs) are emerging pollutants of concern with ubiquitous presence in global ecosystems. MNPs pose potential implications for human health; however, the health impacts of MNP exposures are not yet understood. Recent evidence suggests that MNPs can cross the placental barrier, underlying the urgent need to understand their impact on reproductive health and development. </sec> <sec> <title>OBJECTIVE</title> The Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics (AURORA) project will investigate MNP exposures and their biological and health effects during pregnancy and early life, which are critical periods due to heightened vulnerability to environmental stressors. The AURORA project will enhance exposure assessment capabilities for measuring MNPs, MNP-associated chemicals, and plastic additives in human tissues, including placenta and blood. </sec> <sec> <title>METHODS</title> In this interdisciplinary project, we will advance methods for in-depth characterization and scalable chemical analytical strategies, enabling high-resolution and large-scale toxicological, exposure assessment, and epidemiological studies. The AURORA project performs observational studies to investigate determinants and health impacts of MNPs by including 800 mother-child pairs from 2 existing birth cohorts and 110 women of reproductive age from a newly established cohort. This will be complemented by toxicological studies using a tiered-testing approach and epidemiological investigations to evaluate associations between maternal and prenatal MNP exposures and health perturbations, such as placental function, immune-inflammatory responses, oxidative stress, accelerated aging, endocrine disruption, and child growth and development. The ultimate goal of the AURORA project is to create an MNP risk assessment framework and identify the remaining knowledge gaps and priorities needed to comprehensively assess the impact of MNPs on early-life health. </sec> <sec> <title>RESULTS</title> In the first 3 years of this 5-year project (2021-2026), progress was made toward all objectives. This includes completion of recruitment and data collection for new and existing cohorts, development of analytical methodological protocols, and initiation of the toxicological tiered assessments. As of September 2024, data analysis is ongoing and results are expected to be published starting in 2025. </sec> <sec> <title>CONCLUSIONS</title> As plastic pollution increases globally, it is imperative to understand the impact of MNPs on human health, particularly during vulnerable developmental stages such as early life. The contributions of the AURORA project will inform future risk assessment. </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/63176 </sec>