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The effects of nanoplastics and microcystin-LR coexposure on Aristichthys nobilis at the early developmental stages

Aquatic Toxicology 2024 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Fei Wang Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Feifan Bao, Fei Wang Feifan Bao, Fei Wang Chaonan Zhang, Fei Wang Fei Wang Fei Wang Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Chaonan Zhang, Feifan Bao, Feifan Bao, Chaonan Zhang, Chaonan Zhang, Fei Wang Daohui Lin, Chaonan Zhang, Feifan Bao, Chaonan Zhang, Fei Wang Feifan Bao, Fei Wang Chaonan Zhang, Chaonan Zhang, Junjie Zhu, Chaonan Zhang, Daohui Lin, Junjie Zhu, Fei Wang Daohui Lin, Fei Wang Chaonan Zhang, Daohui Lin, Fei Wang Chaonan Zhang, Daohui Lin, Fei Wang Daohui Lin, Daohui Lin, Jiang Xu, Jiang Xu, Chaonan Zhang, Jiang Xu, Fei Wang Fei Wang Fei Wang Daohui Lin, Daohui Lin, Junjie Zhu, Jiang Xu, Chaonan Zhang, Chaonan Zhang, Junjie Zhu, Daohui Lin, Daohui Lin, Daohui Lin, Daohui Lin, Daohui Lin, Daohui Lin, Daohui Lin, Fei Wang Fei Wang Fei Wang

Summary

Researchers studied the combined toxic effects of nanoplastics and microcystin-LR, a harmful algal toxin, on bighead carp at early developmental stages. While survival and hatching rates were not significantly affected, the nanoplastics adhered to embryo membranes and the co-exposure activated stress-related gene pathways in the developing fish. The study suggests that the combined presence of nanoplastics and algal toxins in aquaculture environments may pose subtle but measurable risks to fish development.

Body Systems

Immune Musculoskeletal

Nanoplastics (NPs) and microcystin-LR (MC-LR) are two common and harmful pollutants in water environments, especially at aquafarm where are full of plastic products and algae. It is of great significance to study the toxic effects and mechanisms of the NPs and/or MC-LR on fish at the early stage. In this study, the embryo and larvae of a filtering-feeding fish, Aristichthys nobilis, were used as the research objects. The results showed that the survival and hatching rates of the embryo were not significantly affected by the environmental concentration exposure of these two pollutants. Scanning electron microscopy (SEM) observation displayed that NPs adhered to the surface of the embryo membrane. Transcriptomic and bioinformatic analyses revealed that the NPs exposure activated neuromuscular junction development and skeletal muscle fiber in larvae, and affected C5-Branched dibasic acid metabolism. The metabolic and biosynthetic processes of zeaxanthin, xanthophyll, tetraterpenoid, and carotenoid were suppressed after the MC-LR exposure, which was harmful to the retinol metabolism of fish. Excessive production of superoxide dismutase (SOD) was detected under the MC-LR exposure. The MC-LR and NPs coexposure triggered primary immunodeficiency and adaptive immune response, leading to the possibility of reduced fitness of A.nobilis during the development. Collectively, our results indicate that environmental concentration NPs and MC-LR coexposure could cause toxic damage and enhance sick risk in A.nobilis, providing new insights into the risk of NPs and MC-LR on filtering-feeding fish.

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