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Novel insights into the role of bisphenol A (BPA) in genomic instability
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This review examines how bisphenol A (BPA), a chemical widely used in polycarbonate and PVC plastics, contributes to genomic instability beyond its well-known effects as an endocrine disruptor. Researchers found evidence that BPA can damage DNA, disrupt cell division, and interfere with DNA repair mechanisms. The findings suggest that BPA exposure may play a role in promoting the kind of genetic damage that can lead to serious cellular dysfunction.
Bisphenol A (BPA) is a phenolic chemical that has been used for over 50 years in the manufacturing of polycarbonate and polyvinyl chloride plastics, and it is one of the highest volume chemicals produced worldwide. Because BPA can bind to and activate estrogen receptors, studies have mainly focused on the effect of BPA in disrupting the human endocrine and reproductive systems. However, BPA also plays a role in promoting genomic instability and has been associated with initiating carcinogenesis. For example, it has been recently shown that exposure to BPA promotes the formation of single stranded DNA gaps, which may be associated with increased genomic instability. In this review, we outline the mechanisms by which BPA works to promote genomic instability including chromosomal instability, DNA adduct formation, ROS production, and estrogen receptor (ER) activation. Moreover, we define the ways in which BPA promotes both carcinogenesis and resistance to chemotherapy, and we provide critical insights into future directions and outstanding questions in the field.
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Bisphenol A-an Overview on its Effect on Health and Environment
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This review synthesized evidence on bisphenol A (BPA) — a chemical used in polycarbonate plastics and epoxy resins — covering its sources of human exposure, endocrine-disrupting mechanisms, and associations with metabolic, reproductive, and developmental health outcomes.
Stem cells as sensitive targets of bisphenol-A: a comprehensive review of the effects across multiple populations
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This review pulls together recent research on BPA, a chemical found in plastics, food packaging, and medical devices, showing it can damage stem cells, the body's building blocks for repairing and renewing tissues. Scientists found BPA disrupts how these cells grow, use energy, and communicate, and may even cause changes that affect future generations, especially concerning since BPA often occurs alongside microplastics in our environment. While the findings raise real health concerns, researchers note that studies vary widely in design, so more standardized research is needed before we can fully understand the risk to humans.
Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
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This review examines the molecular mechanisms by which bisphenol A (BPA), a common endocrine-disrupting chemical found in plastics, may contribute to various health conditions. Researchers analyzed BPA's effects on mesenchymal stem cells and fat cell development, as well as its uses in dental, orthopedic, and industrial applications. The study suggests that BPA exposure can alter multiple molecular pathways involved in immune, metabolic, and cellular processes.
The Effects of Bisphenol A of Polycarbonate Plastics on Various Blood and Fertility Parameters, along with Histological Changes in Male Albino Rats
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This review examined the effects of bisphenol A (BPA) leaching from polycarbonate plastics on blood parameters and fertility indicators, summarizing animal and human studies showing endocrine-disrupting effects. BPA exposure was associated with hormonal imbalances and impaired reproductive outcomes.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review.
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This review of existing research found that tiny plastic particles (microplastics and nanoplastics) can damage DNA in many different living things, from fish to human cells. The plastic particles cause this damage by creating harmful molecules called free radicals, disrupting the body's ability to repair DNA, and triggering inflammation. These findings suggest that the growing amount of plastic pollution in our environment could pose serious health risks to humans and wildlife.
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