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The Potential Mechanisms Involved in the Disruption of Spermatogenesis in Mice by Nanoplastics and Microplastics

Biomedicines 2024 14 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yixian Wen, Huilian Zhang, Yixian Wen, Yi Li, Jing Cai, Yi Li, Huilian Zhang, Yi Li, Manyao Yu, Jing Cai, Manyao Yu, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Jinyi Liu, Fei Han Fei Han Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Yixian Wen, Fei Han Yixian Wen, Fei Han Jinyi Liu, Jinyi Liu, Fei Han Fei Han Fei Han

Summary

Researchers examined how polystyrene nanoplastics and microplastics disrupt spermatogenesis in mice through different molecular mechanisms. The study found that nanoplastics primarily affected retinoic acid metabolism, while microplastics influenced pyruvate and thyroid hormone metabolism, suggesting that particle size determines distinct pathways of reproductive harm in male mammals.

Body Systems

Endocrine Reproductive

Models

Mouse

PS-NPs were predominantly involved in regulating retinoic acid metabolism, whereas PS-MPs primarily influenced pyruvate metabolism and thyroid hormone metabolism. Our results highlight the different molecular mechanisms of PS-NPs and PS-MPs in the impairment of spermatogenesis in male mammals for the first time, providing valuable insights into the precise mechanisms of PS-NPs and PS-MPs in male reproduction.

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