Tread lightly: immuno-toxicological health effects of traffic-related polymers in healthy adults.
Zenodo (CERN European Organization for Nuclear Research)2024
Score: 45
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Martin Brits,
Martin Brits,
Martin Brits,
Lorenzo Scibetta,
Esther S. Lenssen,
Esther S. Lenssen,
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Lorenzo Scibetta,
Esther S. Lenssen,
Esther S. Lenssen,
Esther S. Lenssen,
Lorenzo Scibetta,
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Lorenzo Scibetta,
Esther S. Lenssen,
Lorenzo Scibetta,
Esther S. Lenssen,
Tim L P Skrabanja,
Esther S. Lenssen,
Lorenzo Scibetta,
Lorenzo Scibetta,
Lorenzo Scibetta,
Lorenzo Scibetta,
Nienke Vrisekoop,
Tim L P Skrabanja,
Esther S. Lenssen,
Esther S. Lenssen,
Tim L P Skrabanja,
Esther S. Lenssen,
Tim L P Skrabanja,
Esther S. Lenssen,
Tim L P Skrabanja,
Tim L P Skrabanja,
Lorenzo Scibetta,
Lorenzo Scibetta,
Tim L P Skrabanja,
Tim L P Skrabanja,
Tim L P Skrabanja,
Tim L P Skrabanja,
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Nienke Vrisekoop,
Raymond Pieters
Lorenzo Scibetta,
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Nienke Vrisekoop,
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Kas Adriaans,
Tim L P Skrabanja,
Lorenzo Scibetta,
Lorenzo Scibetta,
Lorenzo Scibetta,
Lorenzo Scibetta,
Lorenzo Scibetta,
Martin Brits,
Marja Lamoree,
Marja Lamoree,
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Kas Adriaans,
Kas Adriaans,
Tim L P Skrabanja,
Marja Lamoree,
Marja Lamoree,
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Kas Adriaans,
Raymond Pieters
Raymond Pieters
Laura Caiazzo,
Laura Caiazzo,
Raymond Pieters
Tim L P Skrabanja,
Tim L P Skrabanja,
Tim L P Skrabanja,
Tim L P Skrabanja,
Nienke Vrisekoop,
Raymond Pieters
Nienke Vrisekoop,
Gerard Hoek,
Nienke Vrisekoop,
Gerard Hoek,
Raymond Pieters
Laura Caiazzo,
Gerard Hoek,
Gerard Hoek,
Nienke Vrisekoop,
Raymond Pieters
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Annemijne Van Den Berg,
Esther S. Lenssen,
Raymond Pieters
Raymond Pieters
Esther S. Lenssen,
Annemijne Van Den Berg,
Laura Caiazzo,
Laura Caiazzo,
Raymond Pieters
Nienke Vrisekoop,
Kas Adriaans,
Raymond Pieters
Nienke Vrisekoop,
Raymond Pieters
Raymond Pieters
Kas Adriaans,
Kas Adriaans,
Kas Adriaans,
Laura Caiazzo,
Laura Caiazzo,
Raymond Pieters
Marja Lamoree,
Raymond Pieters
Maria Rita Montereali,
Maria Rita Montereali,
Esther S. Lenssen,
Gerard Hoek,
Raymond Pieters
Raymond Pieters
Raymond Pieters
Raymond Pieters
Esther S. Lenssen,
Gerard Hoek,
Gerard Hoek,
Gerard Hoek,
Raymond Pieters
Martin Brits,
Martin Brits,
Martin Brits,
Martin Brits,
Gerard Hoek,
Marja Lamoree,
Marja Lamoree,
Marja Lamoree,
Nienke Vrisekoop,
Gerard Hoek,
Marja Lamoree,
Nienke Vrisekoop,
Raymond Pieters
Summary
Researchers studied health effects in commuters exposed to traffic-related micro- and nanoplastics, primarily from tire wear, comparing outcomes between high-exposure and low-exposure groups. The study found evidence of immunotoxicological effects linked to airborne polymer particle exposure from road traffic.
One of the predominant sources releasing micro- and nanoplastics (MNPs) into the atmosphere is motorized road traffic tyre wear. It is unclear what exposure levels of these MNPs and their potential short-term health effects are. The objective was to study health effects associated with exposure to traffic-related MNPs in healthy adults. In 2022-2023 a panel of 23 volunteers (23 – 38 yrs) visited three traffic-locations for 4 hrs: a stop-and-go busy road, a highway and an urban background location with varying driving styles. Before and directly after each visit, and the following morning, spirometry tests were performed, respiratory symptoms were noted and blood was collected to assess subtypes of white blood cell (WBC) counts, activation markers and cytokine levels. Quartz filters collected with a high-volume sampler, and blood samples, were analyzed using double-shot pyrolysis gas-chromatography/ mass-spectrometry for the mass of synthetic- an natural rubber markers. Exposure levels of other traffic-related major air pollutants were quantified, including black carbon, ultrafine particles, iron and copper. Associations between air pollutants and pairwise differences in endpoints were assessed using mixed model analysis, adjusting for multiple confounders. Rubber polymer levels were respectively 3.5-4.5x higher at the stop-and-go location compared to the park and 1.1-1.5x higher than the highway location. Polymers had a moderate to low correlation with other pollutants, except black carbon. Preliminary results indicate no consistent associations between polymers and other air pollutants and spirometry or symptoms. Increased associations were observed between pyrolysates and relative counts of WBCs (5.8-20No consistent associations were observed between traffic-related MNPs and respiratory health. Increased associations between MNP concentrations and subtypes of WBCs, might indicate an increase in inflammatory responses in healthy adults. Also see: https://micro2024.sciencesconf.org/558831/document