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From the synthesis of labeled nanoplastic model materials (isotopic and metallic) to their use in ecotoxicological studies with the detection and quantification analytical methods.
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Researchers synthesized isotopically and metallically labeled nanoplastic model materials to enable tracking and quantification of plastic nanoparticles in complex biological and environmental matrices at trace concentrations. The labeled models supported mechanistic studies of nanoplastic fate and exposure by allowing detection at environmentally relevant concentrations not achievable with conventional unlabeled particles.
Evaluating the impact of nanoplastics within an environmental compartment or an organism requires to localize and quantify the plastic moieties. Isolating such small organic compounds in environmental concentration (ppt-ppm) within an organic complex matrix remains a scientific challenge. Scientists are known to offer workarounds to get responses and the use of labeled nanoplastic model materials (labeled-NP) developed in research laboratories, is one such method. Several labeled-NP are described in the literature, and they should come with their analytical protocols to confirm their potential for use in (eco-)toxicological studies. In this context, we propose to present some of the works developed at IPREM based on labeled-NP, ensuring that the marker cannot be released, does not change the properties of the nanoplastic, nor induces toxicity while being quantified in complex media. First, we will focus the synthesis of isotopically labeled-NP with surface mimicking oxidized aged plastics. Quantification methods were optimized and applied within two ecotoxicological studies. (i) Daphnia magna were exposed to deuterium-labeled NP and analyzed by pyrolysis coupled with gas chromatography and mass spectrometry (Py-GC/MS). (ii) Artemia sp. were exposed to 13C-labeled-NP and analyzed using elemental analysis coupled with stable isotope ratio mass spectrometry (EA-IRMS) and Py-GC/MS. Parameters studied included depuration, exposure time and concentration, organism's gender. Results in terms of mortality and accumulation of labeled-NP will be provided. Second, metal-labeled-NP will be presented. Each nanoplastic contains a gold nanoparticle big enough to be quantitatively detected by SP-ICP/MS and small enough to not increase the mass density of the nanoplastics. The characterization of the gold-NP will be detailed before presenting the results showing their potential in ecotoxicologial study when exposed to Daphnia magna. This presentation reports the synthesis methods to elaborate isotopic- and gold-labeled nanoplastics with their quantification in complex matrices for ecotoxicological studies conducted under realistic conditions. Also see: https://micro2024.sciencesconf.org/559178/document
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This study developed labeled nanoplastic model materials using isotopic and metallic tracers to enable tracking and quantification of nanoplastics in complex biological and environmental matrices at environmentally relevant concentrations. Labeled particles allowed localization and measurement of nanoplastics at levels not detectable by conventional methods, advancing mechanistic exposure studies.
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