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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Detection Methods Environmental Sources Human Health Effects Nanoplastics Sign in to save

From the synthesis of labeled nanoplastic model materials (isotopic and metallic) to their use in ecotoxicological studies with the detection and quantification analytical methods.

Zenodo (CERN European Organization for Nuclear Research) 2024 Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Roxane Danquigny, Roxane Danquigny, Karin Mattsson, Karin Mattsson, Karin Mattsson, Karin Mattsson, Karin Mattsson, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Roxane Danquigny, Karin Mattsson, Karin Mattsson, Karin Mattsson, Karin Mattsson, Stéphanie Reynaud Karin Mattsson, Karin Mattsson, Karin Mattsson, Stéphanie Reynaud Karin Mattsson, Karin Mattsson, Karin Mattsson, Karin Mattsson, Marc Metian, Marc Metian, Sophie Miguel, Sophie Miguel, Marc Metian, Stéphanie Reynaud Karin Mattsson, Karin Mattsson, Sophie Miguel, Sophie Miguel, Marc Metian, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Stéphanie Reynaud Karin Mattsson, Séverine Le Faucheur, Séverine Le Faucheur, Séverine Le Faucheur, Séverine Le Faucheur, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Sophie Miguel, Javier Jimenez-Lamana, Marc Metian, Marc Metian, Stéphanie Reynaud Javier Jimenez-Lamana, Javier Jimenez-Lamana, Stéphanie Reynaud Stéphanie Reynaud Séverine Le Faucheur, Stéphanie Reynaud Marc Metian, Stéphanie Reynaud Karin Mattsson, Marc Metian, Stéphanie Reynaud Stéphanie Reynaud Javier Jimenez-Lamana, Stéphanie Reynaud Bruno Grassl, Stéphanie Reynaud Stéphanie Reynaud Bruno Grassl, Karin Mattsson, Bruno Grassl, Bruno Grassl, Bruno Grassl, Bruno Grassl, Stéphanie Reynaud Séverine Le Faucheur, Karin Mattsson, Bruno Grassl, Stéphanie Reynaud Bruno Grassl, Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Marc Metian, Javier Jimenez-Lamana, Javier Jimenez-Lamana, Marc Metian, Marc Metian, Marc Metian, Javier Jimenez-Lamana, Javier Jimenez-Lamana, Stéphanie Reynaud, Stéphanie Reynaud, Erik Bonjour, Stéphanie Reynaud Stéphanie Reynaud Jame, Patrick, Jame, Patrick, Erik Bonjour, Stéphanie Reynaud Karin Mattsson, Karin Mattsson, Karin Mattsson, Karin Mattsson, Marc Metian, Marc Metian, Marc Metian, Marc Metian, Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Bruno Grassl, Erik Bonjour, Erik Bonjour, Stéphanie Reynaud Bruno Grassl, Bruno Grassl, Bruno Grassl, Stéphanie Reynaud Stéphanie Reynaud, Stéphanie Reynaud, Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud Stéphanie Reynaud

Summary

Researchers synthesized isotopically and metallically labeled nanoplastic model materials to enable tracking and quantification of plastic nanoparticles in complex biological and environmental matrices at trace concentrations. The labeled models supported mechanistic studies of nanoplastic fate and exposure by allowing detection at environmentally relevant concentrations not achievable with conventional unlabeled particles.

Models
Daphnia Invertebrate other

Evaluating the impact of nanoplastics within an environmental compartment or an organism requires to localize and quantify the plastic moieties. Isolating such small organic compounds in environmental concentration (ppt-ppm) within an organic complex matrix remains a scientific challenge. Scientists are known to offer workarounds to get responses and the use of labeled nanoplastic model materials (labeled-NP) developed in research laboratories, is one such method. Several labeled-NP are described in the literature, and they should come with their analytical protocols to confirm their potential for use in (eco-)toxicological studies. In this context, we propose to present some of the works developed at IPREM based on labeled-NP, ensuring that the marker cannot be released, does not change the properties of the nanoplastic, nor induces toxicity while being quantified in complex media. First, we will focus the synthesis of isotopically labeled-NP with surface mimicking oxidized aged plastics. Quantification methods were optimized and applied within two ecotoxicological studies. (i) Daphnia magna were exposed to deuterium-labeled NP and analyzed by pyrolysis coupled with gas chromatography and mass spectrometry (Py-GC/MS). (ii) Artemia sp. were exposed to 13C-labeled-NP and analyzed using elemental analysis coupled with stable isotope ratio mass spectrometry (EA-IRMS) and Py-GC/MS. Parameters studied included depuration, exposure time and concentration, organism's gender. Results in terms of mortality and accumulation of labeled-NP will be provided. Second, metal-labeled-NP will be presented. Each nanoplastic contains a gold nanoparticle big enough to be quantitatively detected by SP-ICP/MS and small enough to not increase the mass density of the nanoplastics. The characterization of the gold-NP will be detailed before presenting the results showing their potential in ecotoxicologial study when exposed to Daphnia magna. This presentation reports the synthesis methods to elaborate isotopic- and gold-labeled nanoplastics with their quantification in complex matrices for ecotoxicological studies conducted under realistic conditions. Also see: https://micro2024.sciencesconf.org/559178/document

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