Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nature Water2024
20 citations
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Score: 65
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Annika Jahnke,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Annika Jahnke,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Annika Jahnke,
Beate I. Escher,
Beate I. Escher,
Beate I. Escher,
Annika Jahnke,
Annika Jahnke,
Alexander Böhme,
S. H. Lips,
S. H. Lips,
Alexander Böhme,
Beate I. Escher,
Martin Krauß,
S. H. Lips,
Werner Brack,
Beate I. Escher,
Jörg Ahlheim,
Mechthild Schmitt‐Jansen,
Alexander Böhme,
Annika Jahnke,
Jörg Ahlheim,
Nils Klüver,
S. H. Lips,
Annika Jahnke,
S. H. Lips,
Luisa Orsini,
S. H. Lips,
S. H. Lips,
Annika Jahnke,
Annika Jahnke,
Annika Jahnke,
Alexander Böhme,
Beate I. Escher,
Martin Krauß,
Nadin Ulrich,
Nadin Ulrich,
Nadin Ulrich,
Mechthild Schmitt‐Jansen,
Maria König,
Mechthild Schmitt‐Jansen,
Dietrich Borchardt,
Annika Jahnke,
Stefan Scholz,
Mechthild Schmitt‐Jansen,
Mechthild Schmitt‐Jansen,
Martin Krauß,
Martin Krauß,
Martin Krauß,
Dietrich Borchardt,
Martin Krauß,
Dietrich Borchardt,
Dietrich Borchardt,
Dietrich Borchardt,
Luisa Orsini,
Dietrich Borchardt,
S. H. Lips,
Karsten Rinke,
Mechthild Schmitt‐Jansen,
Werner Brack,
Luisa Orsini,
Annika Jahnke,
Werner Brack,
S. H. Lips,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Annika Jahnke,
Annika Jahnke,
Annika Jahnke,
Beate I. Escher,
Tobias Schulze
Annika Jahnke,
Annika Jahnke,
Tobias Schulze
Georg Braun,
Annika Jahnke,
Annika Jahnke,
Beate I. Escher,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Maria König,
Werner Brack,
John K. Colbourne,
Martin Krauß,
Annika Jahnke,
Annika Jahnke,
Alexander Böhme,
Alexander Böhme,
Janek Paul Dann,
Jungeun Lee,
Annika Jahnke,
Janek Paul Dann,
Mechthild Schmitt‐Jansen,
Mechthild Schmitt‐Jansen,
Joern Gessner,
Joern Gessner,
Annika Jahnke,
Annika Jahnke,
Annika Jahnke,
Annika Jahnke,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
S. H. Lips,
Annika Jahnke,
Annika Jahnke,
Werner Brack,
Mechthild Schmitt‐Jansen,
Maria König,
Martin Krauß,
Mechthild Schmitt‐Jansen,
Mechthild Schmitt‐Jansen,
Annika Jahnke,
Beate I. Escher,
Annika Jahnke,
Nils Klüver,
Annika Jahnke,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Alexander Böhme,
Alexander Böhme,
Martin Krauß,
Alexander Böhme,
Nadin Ulrich,
Nadin Ulrich,
Jungeun Lee,
Nadin Ulrich,
S. H. Lips,
Markus Weitere,
S. H. Lips,
Werner Brack,
Xiaojing Li,
Mechthild Schmitt‐Jansen,
S. H. Lips,
Werner Brack,
Luisa Orsini,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Annika Jahnke,
Karsten Rinke,
Annika Jahnke,
Annika Jahnke,
Mechthild Schmitt‐Jansen,
Mechthild Schmitt‐Jansen,
Stefan Scholz,
Tobias Schulze
Stephanie Spahr,
Mechthild Schmitt‐Jansen,
Mechthild Schmitt‐Jansen,
Stephanie Spahr,
Nadin Ulrich,
Markus Weitere,
Elisabeth Varga,
Martin Krauß,
Tobias Schulze
Tobias Schulze
Summary
During a toxic algal bloom that killed hundreds of tons of fish in the Oder River in 2022, researchers found that organic micropollutants in the water made the algal toxins even more harmful to human nerve cells in lab tests. While this study focuses on chemical pollution rather than microplastics directly, it demonstrates how mixtures of environmental contaminants can interact to amplify health risks beyond what any single pollutant would cause alone.
Abstract Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.