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PET microplastics increase the risk of insulin resistance and pancreatitis

2024 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Monika Golubska, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Ismena Gałęcka, Ismena Gałęcka, Ismena Gałęcka, Ismena Gałęcka, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Karol Mierzejewski, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Jarosław Całka, Jarosław Całka, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Aleksandra Kurzyńska, Karol Mierzejewski, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Monika Golubska, Jarosław Całka, Jarosław Całka, Ismena Gałęcka, Ismena Gałęcka, Ismena Gałęcka, Ismena Gałęcka, Ismena Gałęcka, Jarosław Całka, Ismena Gałęcka, Ismena Gałęcka, Jarosław Całka, Ismena Gałęcka, Jarosław Całka, Ismena Gałęcka, Ismena Gałęcka, Jarosław Całka, Jarosław Całka, Jarosław Całka, Ismena Gałęcka, Jarosław Całka, Ismena Gałęcka, Jarosław Całka, Jarosław Całka, Jarosław Całka, Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka Jarosław Całka, Jarosław Całka, Jarosław Całka, Jarosław Całka, Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka Iwona Bogacka

Summary

Researchers fed young piglets PET microplastics for four weeks and found significant metabolic changes in their pancreatic tissue, including disrupted fat metabolism and signs of inflammation. Piglets receiving the higher dose showed tissue changes consistent with early pancreatitis, and both dose groups showed markers associated with insulin resistance. The study suggests that microplastic exposure in developing organisms may affect pancreatic function, though more research is needed to understand implications for humans.

Polymers

PET

Body Systems

Endocrine

Abstract Microplastics and their effects on the body have recently been of great concern. Today it is clear that they are not indifferent to human health, but the full spectrum of their impact has not yet been fully described. Pancreatic diseases are becoming increasingly common worldwide, and their etiology is not well understood. Worryingly, these diseases have been increasingly diagnosed in children over the last 20 years, which was previously considered unusual. The aim of the study was therefore to determine the changes in the pancreas caused by PET microplastics in young organisms. For this purpose, the global metabolomic profile of the pancreas of piglets treated with a low (0.1 g/day) or high dose (1 g/day) of PET microplastics for 4 weeks was determined by UPLC-MS analysis. In addition, insulin levels and various biochemical parameters in the blood were analyzed. The study showed that PET microplastics affected the physiological processes in the pancreas at both low and high doses. We found that PET microplastics increased the tissue levels of important metabolites such as glucose, γ-aminobutyric acid, lysophosphatidylcholine or lysophosphatidylethanolamine. In addition, PET microplastics increased blood insulin concentrations and dose-dependently regulated lipase, cholesterol and calcium levels. These results suggest that PET microplastics increase the risk of insulin resistance and pancreatitis.

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