We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
PET microplastics increase the risk of insulin resistance and pancreatitis
AI summary Read the abstract
Researchers fed young piglets PET microplastics for four weeks and found significant metabolic changes in their pancreatic tissue, including disrupted fat metabolism and signs of inflammation. Piglets receiving the higher dose showed tissue changes consistent with early pancreatitis, and both dose groups showed markers associated with insulin resistance. The study suggests that microplastic exposure in developing organisms may affect pancreatic function, though more research is needed to understand implications for humans.
Abstract Microplastics and their effects on the body have recently been of great concern. Today it is clear that they are not indifferent to human health, but the full spectrum of their impact has not yet been fully described. Pancreatic diseases are becoming increasingly common worldwide, and their etiology is not well understood. Worryingly, these diseases have been increasingly diagnosed in children over the last 20 years, which was previously considered unusual. The aim of the study was therefore to determine the changes in the pancreas caused by PET microplastics in young organisms. For this purpose, the global metabolomic profile of the pancreas of piglets treated with a low (0.1 g/day) or high dose (1 g/day) of PET microplastics for 4 weeks was determined by UPLC-MS analysis. In addition, insulin levels and various biochemical parameters in the blood were analyzed. The study showed that PET microplastics affected the physiological processes in the pancreas at both low and high doses. We found that PET microplastics increased the tissue levels of important metabolites such as glucose, γ-aminobutyric acid, lysophosphatidylcholine or lysophosphatidylethanolamine. In addition, PET microplastics increased blood insulin concentrations and dose-dependently regulated lipase, cholesterol and calcium levels. These results suggest that PET microplastics increase the risk of insulin resistance and pancreatitis.
More Papers Like This
Ingested PET microplastics alter the metabolomic profile of the porcine pancreas
AI summary Read the abstract
Researchers fed young pigs low and high doses of PET microplastics for four weeks and analyzed changes in pancreatic metabolic profiles using mass spectrometry. They found that microplastic ingestion altered the metabolomic profile of the pancreas, with dose-dependent changes in metabolic pathways. The study suggests that dietary microplastic exposure may affect pancreatic function, raising questions about potential long-term metabolic health impacts.
PET microplastics induce lipotoxicity in the porcine pancreas
AI summary Read the abstract
Researchers exposed pigs to PET microplastics for four weeks and found dose-dependent changes in pancreatic protein profiles, with the higher dose altering 17 proteins involved in fatty acid synthesis, lipid peroxidation, and digestive enzyme production. Free fatty acid levels increased significantly at the higher dose, indicating lipotoxic stress in pancreatic tissue. The study suggests a novel pathway through which microplastics may contribute to metabolic disturbances by impairing pancreatic function.
Oral exposure to PET microplastics induces the pancreatic immune response and oxidative stress in immature pigs
AI summary Read the abstract
Researchers fed young pigs PET microplastics (the type found in plastic bottles) and found that the particles triggered immune responses and oxidative stress in the pancreas, the organ that produces insulin. Higher doses caused changes in 86 genes related to immune function and cellular stress. Since pigs are biologically similar to humans, this study raises questions about whether microplastic exposure could contribute to pancreatic problems, including diabetes risk.
PET microplastics induce lipotoxicity in the porcine pancreas
AI summary Read the abstract
Researchers used proteomic analysis to study the effects of PET microplastics on the porcine pancreas after four weeks of exposure at low and high doses. The study found that PET microplastics induced lipotoxicity in the pancreas, disrupting lipid metabolism pathways and suggesting that microplastic ingestion may affect pancreatic function through altered protein expression profiles.
PET microplastics induce lipotoxicity in the porcine pancreas
AI summary Read the abstract
Researchers used proteomic analysis to study the effects of PET microplastics on the porcine pancreas after four weeks of exposure at low and high doses. The study found that PET microplastics induced lipotoxicity in the pancreas, disrupting lipid metabolism pathways and suggesting that microplastic ingestion may affect pancreatic function through altered protein expression profiles.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.