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Assessing toxicity of amorphous nanoplastics in airway- and lung epithelial cells using air-liquid interface models
Summary
Researchers tested four types of nanoplastics on human airway and lung cells using a model that mimics real breathing conditions, and found that polystyrene, PVC, nylon, and polypropylene nanoplastics did not cause significant cell death or inflammation at the concentrations tested. While copper oxide particles (used as a positive control) did cause inflammation, the plastic particles did not trigger the same response. This is a reassuring finding, though the authors note that long-term and repeated exposure effects still need to be studied.
Although CuO induced inflammation, PS failed to elicit an inflammatory response in any of our models. For the first time, we show that PVC, PA and PP do not induce cell death or inflammation in a BEAS-2B ALI model.