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DO BIOFILME AO BIOCONTROLE: AVANÇOS NA COMPREENSÃO E PREVENÇÃO DA CÁRIE DENTÁRIA CAUSADA POR Streptococcus mutans
Summary
This review examines the virulence factors of Streptococcus mutans that promote acid-resistant dental biofilm formation and caries progression, and surveys emerging biocontrol alternatives to conventional fluoride and chlorhexidine treatments, including remineralizing agents, probiotics, and microbiome-modulating therapies that target pathogenic bacteria without disrupting beneficial oral flora.
RESUMO:Streptococcus mutans, uma bactria gram-positiva associada crie dentria, possui fatores de virulncia que promovem a formao de biofilmes cidos e resistentes no esmalte dentrio, intensificando a desmineralizao e a progresso das cries.Alm de afetar a sade bucal, S. mutans pode contribuir para doenas sistmicas, como endocardite bacteriana.Os tratamentos convencionais, como flor e clorexidina, apresentam limitaes e efeitos colaterais, o que impulsiona a busca por alternativas teraputicas que modulam o microbioma oral sem prejudicar as bactrias benficas.A aplicao de remineralizantes, probiticos e peptdeos antimicrobianos seletivos (STAMPs) mostra-se promissora para controlar o biofilme de S. mutans.
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