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Abstract 4138321: Marine Microplastic Levels and the Prevalence of Cardio-Metabolic Diseases in Coastline Counties: An Ecological Analysis

Circulation 2024 Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Bhargav Makwana, Sumanth Khadke, Sumanth Khadke, Sumanth Khadke, Ashish Kumar, Ashish Kumar, Ashish Kumar, Khurram Nasir, Khurram Nasir, Sarju Ganatra, Khurram Nasir, Sudip Sheth, Sourbha S. Dani, Sourbha S. Dani, Rishi K. Wadhera, Rishi K. Wadhera, Sudip Sheth, Rikin Shah, Rikin Shah, Rikin Shah, Sudip Sheth, Rishi K. Wadhera, Sudip Sheth, Sudip Sheth, Yixin Kong, Sumanth Khadke, Yixin Kong, Sadeer Al‐Kindi, Sumanth Khadke, Yixin Kong, Ashish Kumar, Ana Navas‐Acién, Ana Navas‐Acién, Ana Navas‐Acién, Ashish Kumar, Gary Adamkiewicz, Khurram Nasir, Gary Adamkiewicz, Khurram Nasir, Gary Adamkiewicz, Sanjay Rajagopalan, Sanjay Rajagopalan, Sanjay Rajagopalan Rishi K. Wadhera, Rishi K. Wadhera, Sanjay Rajagopalan Sanjay Rajagopalan Sanjay Rajagopalan Sanjay Rajagopalan, Yixin Kong, Sadeer Al‐Kindi, Sadeer Al‐Kindi, Yixin Kong, Sadeer Al‐Kindi, Ana Navas‐Acién, Ana Navas‐Acién, Sourbha S. Dani, Sourbha S. Dani, Sourbha S. Dani, Susan D. Moffatt‐Bruce, Gary Adamkiewicz, Gary Adamkiewicz, Susan D. Moffatt‐Bruce, Susan D. Moffatt‐Bruce, Sarju Ganatra, Sanjay Rajagopalan, Sanjay Rajagopalan Sanjay Rajagopalan, Sanjay Rajagopalan Sarju Ganatra, Sarju Ganatra, Sadeer Al‐Kindi, Sadeer Al‐Kindi, Susan D. Moffatt‐Bruce, Susan D. Moffatt‐Bruce, Sarju Ganatra, Sarju Ganatra, Sanjay Rajagopalan

Summary

An ecological analysis found a significant positive association between marine microplastic concentrations within 200 nautical miles of US coastlines and the county-level prevalence of type 2 diabetes, coronary artery disease, and stroke, suggesting a population-level link between marine plastic pollution and cardiometabolic disease.

Body Systems

Cardiovascular

Study Type Environmental

Background: Micro- and nanoplastics are an emerging risk factor for the development of cardiovascular diseases. The association of marine microplastic levels (MMLs) with the burden of cardiometabolic diseases at a population level remains unexplored. Aim: To investigate the association between the average microplastic concentration in the ocean water body within 200 nautical miles of US coastline surveyed between 2015 and 2020, assigned to its most adjacent coastline county, and the prevalence of type 2 diabetes (T2D), coronary artery disease (CAD), and stroke in those counties. Methods: Microplastic concentration data within 200 nautical miles of the US coastline was spatially analyzed in ArcGIS Online to calculate mean MMLs. The coastal counties were stratified into four categories based on MMLs in the adjacent ocean water body: low (0-0.005 pieces/m 3 ), medium (0.005-1 pieces/m 3 ), high (1-10 pieces/m 3 ), or very high (≥10 pieces/m 3 ). BRFSS 2019-2020 survey data was used to correlate with the prevalence of type 2 diabetes (T2D), coronary artery disease (CAD), and stroke in these counties. Univariate and population-weighted multivariate quasi-Poisson regression adjusted for median county age, sex, physician access, and baseline community vulnerability theme of the US climate vulnerability index (CVI) was used to evaluate unadjusted and adjusted associations between disease prevalence and MMLs. Results: The mean age of the population was 43 ± 6 years. The mean prevalence of T2D, CAD, and stroke was significantly higher in counties with very high MMLs (13.03%, 8.94%, and 4.17%, respectively) compared to low MMLs (11.23%, 7.43%, and 3.51%, respectively, p < 0.001). The counties with very high MMLs exhibited an 18% higher adjusted prevalence of T2D (PR: 1.18 [1.13 – 1.23], p < 0.001), 7% higher adjusted prevalence of CAD (PR: 1.07, [1.03 – 1.11], p < 0.001), and 9% higher adjusted prevalence of stroke (PR: 1.09, 95% CI: 1.05 – 1.13, p < 0.001) compared to those with low levels. Conclusion: Our study establishes a significant association between marine microplastic levels and cardiometabolic disease prevalence in coastal counties.

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