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Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury
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Researchers found that nano-selenium particles could reduce liver inflammation caused by polystyrene microplastics in mice by regulating mitochondrial dynamics and modulating the NF-kB/NLRP3 inflammatory pathway. The study suggests that selenium nanoparticles may help counteract the inflammatory damage that microplastics cause in liver tissue, offering a potential avenue for mitigating microplastic-related organ injury.
To summarize, the use of SeNPs hindered inflammation by regulating mitochondrial dynamics, thus relieving liver damage caused by PS-MPs in mice. The anticipated outcomes offer new research directions that can be referenced in terms of inflammatory injuries caused by PS-MPs.
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Microplastic-induced NAFLD: Hepatoprotective effects of nanosized selenium
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In mice, polystyrene microplastics caused fat accumulation and degeneration in the liver, a pattern resembling nonalcoholic fatty liver disease. Mice also given selenium nanoparticles made by a yak-derived Bacillus cereus strain had much less of this damage. Microplastics suppressed the Ppar-alpha and Nrf2 pathways, and the nanoparticles activated them.
Inulin-modified nano selenium biocomposite with dual-targeting capability mitigates polystyrene nanoplastic-induced hepatic ferroptosis
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Tiny plastic particles that we're increasingly exposed to (called nanoplastics) can damage the liver by triggering a harmful type of cell death, partly by throwing off the balance of gut bacteria. In this mouse study, researchers found that a specially modified selenium supplement helped protect the liver from this damage, both by boosting the body's natural antioxidant defenses and by restoring healthy gut bacteria function. While this is early-stage animal research, it points to a promising future strategy for protecting ourselves from the health effects of plastic pollution that's now nearly impossible to avoid.
Nano-selenium ameliorates microplastics-induced injury: Histology, antioxidant capacity, immunity and intestinal microbiota of grass carp (Ctenopharyngodon idella)
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Researchers tested whether nano-selenium supplements could protect grass carp from damage caused by polystyrene microplastics. They found that nano-selenium reduced the tissue damage, oxidative stress, and immune suppression caused by microplastic exposure, and helped restore healthy gut bacteria. The study suggests that dietary nano-selenium may be a practical strategy for protecting farmed fish from the harmful effects of microplastic pollution in aquatic environments.
Oxidative stress-activated Nrf2 remitted polystyrene nanoplastic-induced mitochondrial damage and inflammatory response in HepG2 cells
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Researchers discovered that polystyrene nanoplastics damage human liver cells by causing oxidative stress and mitochondrial damage, but the cells activate a protective pathway called Nrf2 to fight back. When the Nrf2 defense was blocked, the damage from nanoplastics became significantly worse, confirming its protective role. This study helps explain how the liver tries to defend itself against nanoplastic toxicity, and suggests that people with weaker antioxidant defenses may be more vulnerable to liver damage from plastic exposure.
Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk
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Researchers discovered that very small polystyrene nanoparticles (20 nanometers) cause liver damage in mice by accumulating inside immune cells called macrophages, disrupting their energy-producing structures (mitochondria), and triggering a form of cell death that then spreads damage to liver cells. This study reveals a specific mechanism by which nanoplastic exposure could harm the liver, an organ critical for filtering toxins from the body.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.