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Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury

Nutrients 2024 10 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Qi Shen, Jiakui Li Qi Shen, Jia Liu, Jia Liu, Jiakui Li Donghai Zhou, Donghai Zhou, Jiakui Li Donghai Zhou, Jiakui Li

Summary

Researchers found that nano-selenium particles could reduce liver inflammation caused by polystyrene microplastics in mice by regulating mitochondrial dynamics and modulating the NF-kB/NLRP3 inflammatory pathway. The study suggests that selenium nanoparticles may help counteract the inflammatory damage that microplastics cause in liver tissue, offering a potential avenue for mitigating microplastic-related organ injury.

Body Systems

Hepatic Immune

Models

Mouse

To summarize, the use of SeNPs hindered inflammation by regulating mitochondrial dynamics, thus relieving liver damage caused by PS-MPs in mice. The anticipated outcomes offer new research directions that can be referenced in terms of inflammatory injuries caused by PS-MPs.

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