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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Remediation Sign in to save

Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH‐Dependent and Attenuates Their Bioavailability and Toxicity

Small Science 2024
Zongshan Zhao, Zongshan Zhao, Jiaqiang Yao, Haimei Li, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Yanmin Long, Lei Feng, Henner Hollert, Xingchen Zhao

Summary

Researchers investigated how pH affects the binding of perfluoroalkyl substances (PFAS) to the protein corona that forms on nanoplastic surfaces in biological fluids. pH-dependent changes in protein corona composition significantly altered PFAS binding capacity, with implications for how nanoplastics transport PFAS in the body.

Nanoplastics Nanoplastics serve as vectors for perfluoroalkyl pollutants in biological fluids, influencing protein binding behavior. Low pH weakens PFOS interactions while leaving PFOA unaffected, with PFOS still exhibiting greater serum persistence. Additionally, nanoplastics and serum albumin lower the cellular uptake and cytotoxicity of perfluoroalkyls by reducing their bioavailability. More in article number 2400255, Xingchen Zhao and co-workers.

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