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Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH‐Dependent and Attenuates Their Bioavailability and Toxicity
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Researchers investigated how pH affects the binding of perfluoroalkyl substances (PFAS) to the protein corona that forms on nanoplastic surfaces in biological fluids. pH-dependent changes in protein corona composition significantly altered PFAS binding capacity, with implications for how nanoplastics transport PFAS in the body.
Nanoplastics Nanoplastics serve as vectors for perfluoroalkyl pollutants in biological fluids, influencing protein binding behavior. Low pH weakens PFOS interactions while leaving PFOA unaffected, with PFOS still exhibiting greater serum persistence. Additionally, nanoplastics and serum albumin lower the cellular uptake and cytotoxicity of perfluoroalkyls by reducing their bioavailability. More in article number 2400255, Xingchen Zhao and co-workers.
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