Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Food & Water Policy & Risk Remediation Sign in to save

Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure

PLoS ONE 2024 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Mohammed Aufy, Mahmoud Abd‐Elkareem, Mahmoud Abd‐Elkareem, Medina Mustafic, Medina Mustafic, Mostafa A. Abdel-Maksoud, Mohamed H. Kotob Mohamed H. Kotob Mohamed H. Kotob Mostafa A. Abdel-Maksoud, Ali Hakamy, Mohammed Aufy, Veronika Barešová, Mohammed Aufy, Akram A. Alfuraydi, Mostafa A. Abdel-Maksoud, Akram A. Alfuraydi, Mostafa A. Abdel-Maksoud, Mahmoud Ashry, Jana Lubec, Ayman Amer, Christian Studenik, Ahmed M. Hussein, Mohamed H. Kotob

Summary

Researchers identified age-related changes in lung tissue involving increased activity of specific proteases (cathepsins G and X) and matrix metalloproteinases in older rat lungs. The study suggests these enzymes contribute to the breakdown of structural proteins in the lung's extracellular matrix, providing insights into mechanisms underlying age-associated changes in lung tissue integrity.

Body Systems

Respiratory

Models

Rat

The findings indicate an age-related upregulation of cathepsins G and X along with heightened MMP activity in old rat lung tissues, potentially contributing to the degradation of fibronectin within the ECM. These alterations highlight potential mechanisms underlying age-associated changes in lung tissue integrity and provide insights into protease-mediated ECM remodeling in the context of aging lungs.

Read via DOI Download PDF

Share this paper

Post Share Share Pin Email